C3NHU6 · HOSA_SULIN

Function

function

Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site122-oxoglutarate (UniProtKB | ChEBI)
Binding site13Mg2+ (UniProtKB | ChEBI)
Binding site762-oxoglutarate (UniProtKB | ChEBI)
Binding site1362-oxoglutarate (UniProtKB | ChEBI)
Binding site1702-oxoglutarate (UniProtKB | ChEBI)
Binding site198Mg2+ (UniProtKB | ChEBI)
Binding site200Mg2+ (UniProtKB | ChEBI)
Active site292Proton acceptor

GO annotations

AspectTerm
Molecular Functionhomocitrate synthase activity
Molecular Functionmetal ion binding
Biological Processlysine biosynthetic process via aminoadipic acid

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homocitrate synthase
  • EC number
  • Short names
    HCS

Gene names

    • Ordered locus names
      YN1551_1618

Organism names

Accessions

  • Primary accession
    C3NHU6

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002133211-461Homocitrate synthase

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-259Pyruvate carboxyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    461
  • Mass (Da)
    50,825
  • Last updated
    2009-06-16 v1
  • Checksum
    1067BD15BAEF4646
MIKVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVKLKKEGIITSEIVGHSRAVKRDIEIAAELEVDRIAIFYGVSDLHLKAKHKATREEALRTIAETISYAKNHGVKVRFTAEDGSRTDFDFLVTVSKTARDAGADRVSIADTVGILYPSKTKELFSALTREVPNLEFDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGERVGIVPLQQIAAAIKYHFGIEVVKLDKLQYVSSLVEKYSGIPMPPNYPITGDYAFLHKAGVHVAGVLNDPRTYEFMPPETFGRTRDYTIDKYTGKHALRDKYEKLGVKISDAEMDQILAKIKSNTTIRFYRDVDLLELAEEVTGRVLKPRPPEQIEALISVKCDSNVYTTSVTRRLSVINGVKEVMEISGDYDILVKVQAKDSNELNQIIESIRATKGVRSTLTSLVLKKM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001404
EMBL· GenBank· DDBJ
ACP48706.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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