C3LWP7 · LLDD_VIBCM
- ProteinL-lactate dehydrogenase
- GenelldD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids378 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.
Catalytic activity
- (S)-lactate + A = AH2 + pyruvate
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 24 | substrate | ||||
Sequence: Y | ||||||
Binding site | 106 | FMN (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 127 | FMN (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 129 | substrate | ||||
Sequence: Y | ||||||
Binding site | 155 | FMN (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 164 | substrate | ||||
Sequence: R | ||||||
Binding site | 251 | FMN (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Active site | 275 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 278 | substrate | ||||
Sequence: R | ||||||
Binding site | 306-330 | FMN (UniProtKB | ChEBI) | ||||
Sequence: DSGIRTGLDVVRMLALGADCTMLGR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | FMN binding | |
Molecular Function | lactate dehydrogenase activity | |
Biological Process | lactate oxidation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameL-lactate dehydrogenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio
Accessions
- Primary accessionC3LWP7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000383451 | 1-378 | L-lactate dehydrogenase | |||
Sequence: MIISASTDYRAAAKAKLPPFLFHYIDGGSYGEHTLRRNTDDLADIALRQRVLSDMSELSLETELFGEKMALPIALSPVGLTGMYARRGEVQAAQAAEAKGIPFTLSTVSVCPIEEVAPSIHRPIWFQLYVLKDRGFMKNVLERAKAAGVKNLVFTVDMPVPGARYRDMHSGMSGPNAAMRRVLQAMAHPSWAWDVGLLGKPHDLGNISKYRGSPTKLEDYIGWLGANFDPSISWKDLEWIRDFWDGPMIIKGILDTEDAKDAVRFGADGIVVSNHGGRQLDGVLSTVQALPAIADAVKGDLKILVDSGIRTGLDVVRMLALGADCTMLGRSFIYALAAQGRAGVENLLDLYEKEMRVAMTLTGAKSIAELSRDSLVKR |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-378 | FMN hydroxy acid dehydrogenase | ||||
Sequence: MIISASTDYRAAAKAKLPPFLFHYIDGGSYGEHTLRRNTDDLADIALRQRVLSDMSELSLETELFGEKMALPIALSPVGLTGMYARRGEVQAAQAAEAKGIPFTLSTVSVCPIEEVAPSIHRPIWFQLYVLKDRGFMKNVLERAKAAGVKNLVFTVDMPVPGARYRDMHSGMSGPNAAMRRVLQAMAHPSWAWDVGLLGKPHDLGNISKYRGSPTKLEDYIGWLGANFDPSISWKDLEWIRDFWDGPMIIKGILDTEDAKDAVRFGADGIVVSNHGGRQLDGVLSTVQALPAIADAVKGDLKILVDSGIRTGLDVVRMLALGADCTMLGRSFIYALAAQGRAGVENLLDLYEKEMRVAMTLTGAKSIAELSRDSLVKR |
Sequence similarities
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length378
- Mass (Da)41,291
- Last updated2009-06-16 v1
- Checksum8310DF5B3F217ADC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001234 EMBL· GenBank· DDBJ | ACP07902.1 EMBL· GenBank· DDBJ | Genomic DNA |