C3KUL4 · MURQ_CLOB6

Function

function

Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

Miscellaneous

A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.

Catalytic activity

Pathway

Amino-sugar metabolism; N-acetylmuramate degradation.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site86Proton donor
Active site117

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncarbohydrate binding
Molecular Functioncarbon-oxygen lyase activity
Molecular Functionenzyme binding
Molecular Functionenzyme inhibitor activity
Molecular Functionfructose-6-phosphate binding
Biological Processamino sugar catabolic process
Biological Processglucose homeostasis
Biological ProcessN-acetylmuramic acid catabolic process
Biological Processnegative regulation of glucokinase activity
Biological Processresponse to fructose

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylmuramic acid 6-phosphate etherase
  • EC number
  • Short names
    MurNAc-6-P etherase
  • Alternative names
    • N-acetylmuramic acid 6-phosphate hydrolase
    • N-acetylmuramic acid 6-phosphate lyase

Gene names

    • Name
      murQ
    • Ordered locus names
      CLJ_B1461

Organism names

Accessions

  • Primary accession
    C3KUL4

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002024251-302N-acetylmuramic acid 6-phosphate etherase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain58-221SIS

Sequence similarities

Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    302
  • Mass (Da)
    32,700
  • Last updated
    2009-06-16 v1
  • Checksum
    2473C719A7ED1DC3
MTNISLDKLVTESRNENTKNIDRVETLEMLKMINDEDKKVAEAVEKELIHIAKAVDKIGEAFFNGGRLIYVGAGTSGRLGVLDASECPPTYGVSYDLVRGIIAGGQSAMFKAREGAEDSKKLCIKDLKNINFGKNDILVGIAASGRTPYVIGGLEYANGIGATTISVTCNPESEMSKIANISIAPVVGPEVITGSTRMKAGTAQKMVLNMLSTGAMVKTGKVYGNLMVDLKATNEKLVERAKRIVMQATGSKREQVEKILKETNFDVKLSIFMIESSLDKIKAKEILDKNKGYIVEAIKEIS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001083
EMBL· GenBank· DDBJ
ACQ55035.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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