C2K1N5 · C2K1N5_LACRM

Function

function

Provides the (R)-glutamate required for cell wall biosynthesis.
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site11-12substrate
Binding site43-44substrate
Active site74Proton donor/acceptor
Binding site75-76substrate
Active site185Proton donor/acceptor
Binding site186-187substrate
Binding site290-295substrate
Binding site323Mg2+ (UniProtKB | ChEBI)
Active site352Proton acceptor
Binding site352Mg2+ (UniProtKB | ChEBI)
Binding site353substrate
Binding site437-440substrate
Binding site460substrate
Binding site465-466substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular Functionglutamate racemase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processcell wall organization
Biological Processnucleotide metabolic process
Biological Processpeptidoglycan biosynthetic process
Biological Processpurine nucleoside triphosphate catabolic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )
  • Recommended name
    Glutamate racemase
  • EC number

Gene names

    • Name
      murI
    • ORF names
      HMPREF0539_3070

Organism names

Accessions

  • Primary accession
    C2K1N5

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.
Belongs to the aspartate/glutamate racemases family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    485
  • Mass (Da)
    52,394
  • Last updated
    2009-06-16 v1
  • Checksum
    915CABED65A5D80B
MMNKQPIGFIDSGVGGLTVVKEALHQLPAENTIYLGDQARLPYGPRPAEQVQAFTWQMVNFLLTKHIKMLVIACNTATAAALPLIKARLKIPVIGVIKPGSRAALKATQTGHIGIIATEGTVKSGAYPKALRAKAPNIRLTSLAAPKFVSLVESNEAHSPIAKRVVADTLQPLLHQDIDTLVLGCTHYPILRPIIQNVMGEDVTLIDSGAETVNDVSMLLDYFDLANDGSEVPTHTYYTTGAPSMFDELGESWLELKKPMHAQHVDIDTQPTHFVEPTSEATDKTIVIASKNPGKIKEFKAMFEPAGVTVKSLADFPTVPTVDETGTTFEANARQKADQYAQDLNLPVLADDSGLMVDALDGQPGIRSARYAGDGHNDAANNAKLLAALADVPEEARTATFHTTLVLAKPNHPEADLVVHGDLSGRITAIPRGTDGFGYDPFFLVPALDKTLAELTADEKNEISHRGNAMRALEKVWQAWLEENV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACIZ01000126
EMBL· GenBank· DDBJ
EEN78809.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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