C2ER99 · C2ER99_9LACO

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site9-14substrate
Active site73Proton acceptor
Binding site73Mg2+ (UniProtKB | ChEBI)
Binding site74substrate
Binding site158-161substrate
Binding site181substrate
Binding site186-187substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      HMPREF0548_2195

Organism names

Accessions

  • Primary accession
    C2ER99

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    206
  • Mass (Da)
    22,546
  • Last updated
    2009-06-16 v1
  • Checksum
    2D0AE1A621E7470A
MVKEILFATSNQGKARELKEAFKKAGVDVEIKTNADLDNPPHPIESGHTFETNAKIKAHELADFSKMPTIADDSGLMVDALNGEPGVRSARYAGEAHNDAKNNAKLLAELGGVPEDKRTAKFWTTIVVSMPGKFDKDLVVSGTCSGRILALPQGEDGFGYDPLFYVPEKGKTFAQMTTDEKNEISHRGRAVEKLLQELPAWLAQFE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACGU01000114
EMBL· GenBank· DDBJ
EEJ70932.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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