Genetic variations in tumor ecrosis factor related apoptosis-inducing ligand receptor-1 (TRAIL-R1) gene and the susceptibility to b-cell non-hodgkin lymphoma (B-NHL) in Egypt.
Downregulation of death receptor 4 is tightly associated with positive response of EGFR mutant lung cancer to EGFR-targeted therapy and improved prognosis.
data suggest that the determination of intracellular co-expression patterns of TRAIL-R1 TRAIL-R2 and TRAIL-R4 provides an innovative and robust method for risk stratification in breast cancer patients beyond conventional prognostic markers.
The G allele of DR4 -A1322G could be considered as a novel independent molecular predictor for hepatitis C virus-related hepatocellular carcinoma in the Egyptian population.
The results provide evidence for the differential impact of fucosylation on signaling via DR4 or DR5. The findings provide novel opportunities to enhance TRAIL sensitivity in colon adenocarcinoma cells that are highly resistant to DR5-mediated apoptosis.
Among 29 immune and inflammatory proteins CXCL1 CD84 and TNFRSF10A were associated with early post-acute coronary syndrome (ACS) after initial ACS-admission
A graphene-based nanocarrier modified with death receptor 4 (DR4) antibody and AKT siRNA has been developed which can synergistically strengthen death receptor-mediated apoptosis and enhance the cancer therapeutic effect in vivo.
Studied TNF receptor superfamily member 10a (TRAILR1) as tumor marker in pancreatic ductal adenocarcinoma (PDAC); found Cytoplasmic TRAIL-R1 to be a positive prognostic marker for patients with PDAC.
data demonstrated a novel effect on TRAIL sensitivity on monocytes and monocytic leukemia cells of IL-4 and suggested that it may be necessary to reconsider the impact of current therapies against IL-4 JAK/STAT and PI3K/Akt pathways with regard to TRAIL sensitivity
These findings suggest that CYP1B1 promotes cancer cell survival through involvement of DNA methylation-mediated DR4 inhibition and that Sp1 may act as key mediator required for oncogenic action.
Data report that DR4 is associated with progression invasion metastasis and survival of colorectal cancer through the Sp1/NF1 switch axis on the genomic locus.
In contrast to apoptosis necroptotic signaling was activated similarly by both DR4- or DR5-specific ligands..Our study provides the first systematic insight into DR4-/DR5-specific signaling in colorectal and pancreatic cancer cells
We found that pharmacological application of Golgi stress leads to induction of death receptors (DRs) 4 and 5. DR4 appears to be primarily responsible for the initiation of cell death downstream of Golgi stress whereas DR5 seems to be more important for cell death triggered by endoplasmic reticulum (ER) stress in specific cancer cell lines
our results demonstrated that nanovectorization of TRAIL with BNNTs enhanced its binding to both DR4 and DR5 receptors at 37 degrees C. Our novel nanovector could potentially be used for delivering TRAIL to cells for cancer treatment
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