C1JCT2 · POLFS_SINV3
- ProteinPolyprotein-FSD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids3390 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Capsid protein VP1-FSD
Assembles with VP1 and VP2 to form an icosahedral capsid. VP1 is about 5 time more abundant than VP1-FSD in the virion.
Capsid protein VP2
Assembles with VP1 and VP1-FSD to form an icosahedral capsid.
RNA-directed RNA polymerase
Replicates genomic and antigenomic RNA.
Catalytic activity
- a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 396-403 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GPGGIGKT | ||||||
Active site | 1258 | For 3C-like protease activity | ||||
Sequence: H | ||||||
Active site | 1295 | For 3C-like protease activity | ||||
Sequence: E | ||||||
Active site | 1381 | For 3C-like protease activity | ||||
Sequence: C | ||||||
Site | 2345-2346 | Cleavage | ||||
Sequence: QM | ||||||
Site | 3016-3017 | Cleavage | ||||
Sequence: QA |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | virion component | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Biological Process | DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | viral RNA genome replication | |
Biological Process | viral translational frameshifting |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended namePolyprotein-FSD
- Cleaved into 5 chains
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Solinviviridae > Invictavirus
- Virus hosts
Accessions
- Primary accessionC1JCT2
Proteomes
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000442447 | ?-?1432 | 3C-like protease | |||
Sequence: MSEKTQTFVQNETHVLDMTSDFKSDLSLEKVTSSVEQTDDLVSKIINNNDLDIKDLSFLRNLLLSTLQYLGIAKFVAINITLSILSILMLLINSCAKFTRIVNLSSHILNIITTLGLYFQVSSMEIEEITQTFENEFGTYDDDKILSHYIKICNLPNRKDVYEYISLNDLKYKIKLPDISFYELKNDILSKNKNLHLWIFQKFTDEFLAMWFGVQPYRISNLREMLVISRQGFIPKDLFNEIRKLCNMGVSVIISFIQSKLFDEPFKKRDCTQALKDASVISSPFDTLWNLISKQVCDNSAEERFTQTILDFTSEFDNFLGIPNYKFAKNQKLVNTISKSLDACAKFIRDCPKDKQTEIFPLQGLHTATVKRRNEILTNVMPKFARQEPFVVLFQGPGGIGKTHLVQQLATKCVNSFYQDHEDDYIEISPDDKYWPPLSGQRVAFFDEAGNLNDLTEDLLFRNIKSICSPAYFNCAAADIEHKISPCPFELVFATVNTDLDTLQSKISSTFGQASVFPIWRRCIVVECSWNEKELGPFNYKNPSGHRSDYSHITMNYMSYDDKTQKLALEKEINFDTLFDMIRLRFRKKQQEHDTKISILNNEIQRQSNSKQHFSVCLYGEPGQGKTYNLNKLITTFANATNLKIGSEEKPSIHIFDDYIKDENDENCSKFMDIYNNKLPNNSVIFSATNVYPKTHFFPTFFLTNLIYAFIQPFKQVGLYRRLGFDGYTDIPNSSVNAPIFVQNFKFYERKQHICYFLSLEFLKNIICYIFFFLYFPLKFIKKIDLIEIKDVNKYVYDRYINFLSLSKQIEIVEYPPNLENVEFDFRFNMNKFHRVSFNNPFELDKYIHFNKNSYENLLHFDWKMYLSPRVKHRLALSYEKFFITISEVNKEIIIEELKRYVLLFKQFNIDPNMEINLGEYGSFYYINGKIHLMTINIESNVSEIPVFTDGDYVYISEHKIPVIDLFDNININSKYNLSFDQSIALNSFKTGDSFYSNAKVRKSLSKFVLLNYQTKFKLYLKEAKDKVKNFIETPIGHLLSILLTIFVICYASFKIYSKFSNFFSKDQAIEDQRKGEKKIKKITNYDSDGVQPQRKGEKKIKKVTNYDSDGVQPQSNVKVEEEIKLVFDPTGQKLLFGNDFTSELETLVELEKDDEEFTKSKIDNKSMAGLRREVRRRRYARSKKAQIEKQEVLTLPDVNGFEGGKPYFQIAEEKARKNLCQIYMIANNENCIASKFSDHIVCYGLFVFKKRLASVGHIVEALKCAPGYNLYAGCDQFNGKLYKMNLVRNYRKRELSVWDVDCPNDFVDLTSFFIPKEELYDAENCNTVLGRFGMNKREVYLYGNCEFIQEFFKVDNKGAQEFGYIDWATVDITLTTGGDCGLPYYICERKKFHNKIMGLHFAGNNVNHKTIGMSALIYKEDLVVWKGAERQ | ||||||
Chain | PRO_0000442446 | 1-? | Helicase | |||
Chain | PRO_0000442445 | 1-3390 | Polyprotein-FSD | |||
Sequence: MSEKTQTFVQNETHVLDMTSDFKSDLSLEKVTSSVEQTDDLVSKIINNNDLDIKDLSFLRNLLLSTLQYLGIAKFVAINITLSILSILMLLINSCAKFTRIVNLSSHILNIITTLGLYFQVSSMEIEEITQTFENEFGTYDDDKILSHYIKICNLPNRKDVYEYISLNDLKYKIKLPDISFYELKNDILSKNKNLHLWIFQKFTDEFLAMWFGVQPYRISNLREMLVISRQGFIPKDLFNEIRKLCNMGVSVIISFIQSKLFDEPFKKRDCTQALKDASVISSPFDTLWNLISKQVCDNSAEERFTQTILDFTSEFDNFLGIPNYKFAKNQKLVNTISKSLDACAKFIRDCPKDKQTEIFPLQGLHTATVKRRNEILTNVMPKFARQEPFVVLFQGPGGIGKTHLVQQLATKCVNSFYQDHEDDYIEISPDDKYWPPLSGQRVAFFDEAGNLNDLTEDLLFRNIKSICSPAYFNCAAADIEHKISPCPFELVFATVNTDLDTLQSKISSTFGQASVFPIWRRCIVVECSWNEKELGPFNYKNPSGHRSDYSHITMNYMSYDDKTQKLALEKEINFDTLFDMIRLRFRKKQQEHDTKISILNNEIQRQSNSKQHFSVCLYGEPGQGKTYNLNKLITTFANATNLKIGSEEKPSIHIFDDYIKDENDENCSKFMDIYNNKLPNNSVIFSATNVYPKTHFFPTFFLTNLIYAFIQPFKQVGLYRRLGFDGYTDIPNSSVNAPIFVQNFKFYERKQHICYFLSLEFLKNIICYIFFFLYFPLKFIKKIDLIEIKDVNKYVYDRYINFLSLSKQIEIVEYPPNLENVEFDFRFNMNKFHRVSFNNPFELDKYIHFNKNSYENLLHFDWKMYLSPRVKHRLALSYEKFFITISEVNKEIIIEELKRYVLLFKQFNIDPNMEINLGEYGSFYYINGKIHLMTINIESNVSEIPVFTDGDYVYISEHKIPVIDLFDNININSKYNLSFDQSIALNSFKTGDSFYSNAKVRKSLSKFVLLNYQTKFKLYLKEAKDKVKNFIETPIGHLLSILLTIFVICYASFKIYSKFSNFFSKDQAIEDQRKGEKKIKKITNYDSDGVQPQRKGEKKIKKVTNYDSDGVQPQSNVKVEEEIKLVFDPTGQKLLFGNDFTSELETLVELEKDDEEFTKSKIDNKSMAGLRREVRRRRYARSKKAQIEKQEVLTLPDVNGFEGGKPYFQIAEEKARKNLCQIYMIANNENCIASKFSDHIVCYGLFVFKKRLASVGHIVEALKCAPGYNLYAGCDQFNGKLYKMNLVRNYRKRELSVWDVDCPNDFVDLTSFFIPKEELYDAENCNTVLGRFGMNKREVYLYGNCEFIQEFFKVDNKGAQEFGYIDWATVDITLTTGGDCGLPYYICERKKFHNKIMGLHFAGNNVNHKTIGMSALIYKEDLVVWKGAERQSKCKFCDVKDIIIAQPDIPKEKYKGYNHEIVWNSLHESSPTTLNEELEHYLNIFPKFTGTIIKHSGDKFYGSVKHSHTQFISKFKTELTVTNGWKLSTAGDCQFESNHISPNTEVMYRVVDVQFNSIFKAFKSQPYIKNFRLIANVYEKDGKQRVTILTIIPVSDFNVKQQTVRQALVPLHLNEDEEVYVTEDVSDIFKTAIKRKQRGILPDVPYETVENETVEILGITHRNMTPEPAQMYKPTPFYKLALKFNLDHKLPVNFNMKDCPQEQKDMMVLDRLGQPNPRITQSLKWAHKDYSPDYELRKYVKEQYMCNIMEYYAGCNLLTEEQILKGYGPNHRLYGALGGMEIDSSIGWTMKELYRVTKKSDVINLDSNGNYSFLNNEAAQYTQELLKISMEQAHNGQRYYTAFNELMKMEKLKPSKNFIPRTFTAQDLNGVLMERWILGEFTARALAWDENCAVGCNPYATFHKFATKFFKFKNFFSCDYKNFDRTIPKCVFEDFRDMLIQANPHMKNEIYACFQTIIDRIQVSGNSILLVHGGMPSGCVPTAPLNSKVNDIMIYTAYVNILRRADRGDITSYRYYRDLVCRLFYGDDVIIAVDDSIADIFNCQTLSEEMKILFGMNMTDGSKSDIIPKFETIETLSFISRFFRPLKHQENFIVGALKKISIQTHFYYATDDTPEHFGQVFKTIQEEAALWEEEYFNKIQSYIQEIIRKFPEISKFFNFESYKSIQKRYIMNGWNEFVKLEKLDLNLNKKKSSKVTGIHSKQYSKFLKFLSRIENEKAALEGNFNKESVNTWYFKMSKAMHLNEIFQKGLISKPLAEFYFNEGQKMWDCNITFRRSKDDLPFTFSGSGTTKACAREQAAEEALVLFSQEDEIVRQINDIQSDCKFCKKMIRYKKLLSGVSIQRQMNVSKITENHVPSAGMMATDPSVAPDSGIATNTQTPSISRVLNPIARALDNPAGTGAPFDKHTYVYNVFTRWPEMSTVVNKSLAAGAEVFKISLDPNKLPKRILQYIQFHKTIIPQIEVQILIGGAAGTVGWLKVGWVPDASTAKKYSLDDLQLVASETINLNSTITMSMIINDSRRNGMFRLTKSDPEPWPGIVCLVEHPITNVQRNDDVNYPVIVSVRLGPDCQLMQPYNDLNLSGGTDPDPDPEPDPDPEPGPDPEPGVDELDLSKYIPNQLIDLLICNSYVPNNVSVDFLSTYPNLNFSIHNITDVVVSSKPYTLALFETESQINSASVWRGDLTQLSVFIQYKFYTRVEAYNKVTTVHTDKWTPNFDGTVYKPVDVKIEHAYGTYELTTMWLTSYGLVMEWSLDESRVFYGTYKTDSNGRRWLIDGNTPIARSDHCFIVSSPDLLSDDKAYYNNPIGAKQGGKLVDGAQIYRIFKTESGGYRSDPFVPETYWPSETPYNADWSGVKMPYQIRKVIQTGNNLAGKHLDGDLKMCAMIRQGSSSTQSTDNYFYPIYVHNFSALLKQMNLILKERKTKYIKFDLQVGGKPFAQMGFGDGAFIGRTTMFRQIRAAITNVILLKNIVGVDDLSGLQALPTSGFADWVVKAQSTNSKFLNDFYNDKISIERQASLGIAAAIGAGQGLFGGLSAQWQWQQQADWSRQMQRERLDMMEKLANINNQARLNQLTQSGAQQRITQQAAYQQQMNALGAGSVSAQNGMYTPSNYTPLPSYKSNTTNYYNNSVYHTDNNITNNPSNTSLTNNINNFNPELFQQQRERMPTPSEAYDNSKGFVPQPGTSKSIATENINPNYKDEEHIYEPIEQQNHEYADIDYNAMNISRENKNSSNFGNVGILDHQYADIDYDAMKIARDQQNSSKFGNVGVLNHQYAELDFSKNNTRKNSQILDNSLYSKTQPSSKMIDNSLYGINPNKMVENQNYEPASMERKNSIYSSNLNSSNNLKFNNIPNFKGPTNLNISGAKPAGFGSGIIQPAINKYTDFSKPN | ||||||
Chain | PRO_0000442448 | ?1433-2345 | RNA-directed RNA polymerase | |||
Sequence: SKCKFCDVKDIIIAQPDIPKEKYKGYNHEIVWNSLHESSPTTLNEELEHYLNIFPKFTGTIIKHSGDKFYGSVKHSHTQFISKFKTELTVTNGWKLSTAGDCQFESNHISPNTEVMYRVVDVQFNSIFKAFKSQPYIKNFRLIANVYEKDGKQRVTILTIIPVSDFNVKQQTVRQALVPLHLNEDEEVYVTEDVSDIFKTAIKRKQRGILPDVPYETVENETVEILGITHRNMTPEPAQMYKPTPFYKLALKFNLDHKLPVNFNMKDCPQEQKDMMVLDRLGQPNPRITQSLKWAHKDYSPDYELRKYVKEQYMCNIMEYYAGCNLLTEEQILKGYGPNHRLYGALGGMEIDSSIGWTMKELYRVTKKSDVINLDSNGNYSFLNNEAAQYTQELLKISMEQAHNGQRYYTAFNELMKMEKLKPSKNFIPRTFTAQDLNGVLMERWILGEFTARALAWDENCAVGCNPYATFHKFATKFFKFKNFFSCDYKNFDRTIPKCVFEDFRDMLIQANPHMKNEIYACFQTIIDRIQVSGNSILLVHGGMPSGCVPTAPLNSKVNDIMIYTAYVNILRRADRGDITSYRYYRDLVCRLFYGDDVIIAVDDSIADIFNCQTLSEEMKILFGMNMTDGSKSDIIPKFETIETLSFISRFFRPLKHQENFIVGALKKISIQTHFYYATDDTPEHFGQVFKTIQEEAALWEEEYFNKIQSYIQEIIRKFPEISKFFNFESYKSIQKRYIMNGWNEFVKLEKLDLNLNKKKSSKVTGIHSKQYSKFLKFLSRIENEKAALEGNFNKESVNTWYFKMSKAMHLNEIFQKGLISKPLAEFYFNEGQKMWDCNITFRRSKDDLPFTFSGSGTTKACAREQAAEEALVLFSQEDEIVRQINDIQSDCKFCKKMIRYKKLLSGVSIQRQ | ||||||
Modified residue | 2346 | N-acetylmethionine; by host | ||||
Sequence: M | ||||||
Chain | PRO_0000442449 | 2346-3016 | Capsid protein VP1-FSD | |||
Sequence: MNVSKITENHVPSAGMMATDPSVAPDSGIATNTQTPSISRVLNPIARALDNPAGTGAPFDKHTYVYNVFTRWPEMSTVVNKSLAAGAEVFKISLDPNKLPKRILQYIQFHKTIIPQIEVQILIGGAAGTVGWLKVGWVPDASTAKKYSLDDLQLVASETINLNSTITMSMIINDSRRNGMFRLTKSDPEPWPGIVCLVEHPITNVQRNDDVNYPVIVSVRLGPDCQLMQPYNDLNLSGGTDPDPDPEPDPDPEPGPDPEPGVDELDLSKYIPNQLIDLLICNSYVPNNVSVDFLSTYPNLNFSIHNITDVVVSSKPYTLALFETESQINSASVWRGDLTQLSVFIQYKFYTRVEAYNKVTTVHTDKWTPNFDGTVYKPVDVKIEHAYGTYELTTMWLTSYGLVMEWSLDESRVFYGTYKTDSNGRRWLIDGNTPIARSDHCFIVSSPDLLSDDKAYYNNPIGAKQGGKLVDGAQIYRIFKTESGGYRSDPFVPETYWPSETPYNADWSGVKMPYQIRKVIQTGNNLAGKHLDGDLKMCAMIRQGSSSTQSTDNYFYPIYVHNFSALLKQMNLILKERKTKYIKFDLQVGGKPFAQMGFGDGAFIGRTTMFRQIRAAITNVILLKNIVGVDDLSGLQALPTSGFADWVVKAQSTNSKFLNDFYNDKISIERQ | ||||||
Chain | PRO_0000442450 | 3017-3390 | Capsid protein VP2 | |||
Sequence: ASLGIAAAIGAGQGLFGGLSAQWQWQQQADWSRQMQRERLDMMEKLANINNQARLNQLTQSGAQQRITQQAAYQQQMNALGAGSVSAQNGMYTPSNYTPLPSYKSNTTNYYNNSVYHTDNNITNNPSNTSLTNNINNFNPELFQQQRERMPTPSEAYDNSKGFVPQPGTSKSIATENINPNYKDEEHIYEPIEQQNHEYADIDYNAMNISRENKNSSNFGNVGILDHQYADIDYDAMKIARDQQNSSKFGNVGVLNHQYAELDFSKNNTRKNSQILDNSLYSKTQPSSKMIDNSLYGINPNKMVENQNYEPASMERKNSIYSSNLNSSNNLKFNNIPNFKGPTNLNISGAKPAGFGSGIIQPAINKYTDFSKPN |
Post-translational modification
Capsid protein VP1-FSD
N-acetylated.
Polyprotein-FSD
Proteolytic cleavages of the polyprotein yield mature proteins.
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 369-543 | SF3 helicase | ||||
Sequence: TVKRRNEILTNVMPKFARQEPFVVLFQGPGGIGKTHLVQQLATKCVNSFYQDHEDDYIEISPDDKYWPPLSGQRVAFFDEAGNLNDLTEDLLFRNIKSICSPAYFNCAAADIEHKISPCPFELVFATVNTDLDTLQSKISSTFGQASVFPIWRRCIVVECSWNEKELGPFNYKNP | ||||||
Domain | 1206-1423 | Peptidase C3 | ||||
Sequence: KPYFQIAEEKARKNLCQIYMIANNENCIASKFSDHIVCYGLFVFKKRLASVGHIVEALKCAPGYNLYAGCDQFNGKLYKMNLVRNYRKRELSVWDVDCPNDFVDLTSFFIPKEELYDAENCNTVLGRFGMNKREVYLYGNCEFIQEFFKVDNKGAQEFGYIDWATVDITLTTGGDCGLPYYICERKKFHNKIMGLHFAGNNVNHKTIGMSALIYKEDL | ||||||
Domain | 1914-2042 | RdRp catalytic | ||||
Sequence: KNFFSCDYKNFDRTIPKCVFEDFRDMLIQANPHMKNEIYACFQTIIDRIQVSGNSILLVHGGMPSGCVPTAPLNSKVNDIMIYTAYVNILRRADRGDITSYRYYRDLVCRLFYGDDVIIAVDDSIADIF | ||||||
Region | 2576-2609 | Disordered | ||||
Sequence: YNDLNLSGGTDPDPDPEPDPDPEPGPDPEPGVDE | ||||||
Compositional bias | 2589-2605 | Acidic residues | ||||
Sequence: PDPEPDPDPEPGPDPEP | ||||||
Region | 3168-3190 | Disordered | ||||
Sequence: TPSEAYDNSKGFVPQPGTSKSIA |
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Ribosomal frameshifting.
C1JCT2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NamePolyprotein-FSD
- NoteProduced by -1 ribosomal frameshifting.
- Length3,390
- Mass (Da)390,107
- Last updated2017-11-22 v2
- Checksum03A54D0B18E90BF6
C1JCT1-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NamePolyprotein
- NoteProduced by -1 ribosomal frameshifting.
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 2589-2605 | Acidic residues | ||||
Sequence: PDPEPDPDPEPGPDPEP |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ528584 EMBL· GenBank· DDBJ | ACO37272.1 EMBL· GenBank· DDBJ | Genomic RNA |