C1IQ78 · C1IQ78_XESMU

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • X01
    • X02
    • X03
    • X04
    • X05
  • Taxonomic lineage
    Eukaryota > Metazoa > Porifera > Demospongiae > Heteroscleromorpha > Haplosclerida > Petrosiidae > Xestospongia

Accessions

  • Primary accession
    C1IQ78

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-41Helical
Transmembrane53-76Helical
Transmembrane88-109Helical
Transmembrane121-146Helical
Transmembrane158-176Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-181Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    181
  • Mass (Da)
    20,303
  • Last updated
    2009-05-26 v1
  • Checksum
    F0D9BE721A5FD9D4
FGMISQIIPTFAAKKQIFGYLGMVYAMVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWVATIFGGSLRLDTPMLWAVGFVFLFTIGGLTGIVLANSSLDVVLHDTYYVVAHFHYVLSMGAVFAIFGGFYYWFGKISGYCYNEVYGKIHFWLMFIGVNLTFFPQHFL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue181

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU716652
EMBL· GenBank· DDBJ
ACH88443.1
EMBL· GenBank· DDBJ
Genomic DNA
EU716653
EMBL· GenBank· DDBJ
ACH88444.1
EMBL· GenBank· DDBJ
Genomic DNA
EU716654
EMBL· GenBank· DDBJ
ACH88445.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271771
EMBL· GenBank· DDBJ
AKQ05934.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271772
EMBL· GenBank· DDBJ
AKQ05935.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271773
EMBL· GenBank· DDBJ
AKQ05936.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271774
EMBL· GenBank· DDBJ
AKQ05937.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271775
EMBL· GenBank· DDBJ
AKQ05938.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271776
EMBL· GenBank· DDBJ
AKQ05939.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271777
EMBL· GenBank· DDBJ
AKQ05940.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271778
EMBL· GenBank· DDBJ
AKQ05941.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271779
EMBL· GenBank· DDBJ
AKQ05942.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271780
EMBL· GenBank· DDBJ
AKQ05943.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271781
EMBL· GenBank· DDBJ
AKQ05944.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271782
EMBL· GenBank· DDBJ
AKQ05945.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271783
EMBL· GenBank· DDBJ
AKQ05946.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271784
EMBL· GenBank· DDBJ
AKQ05947.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271785
EMBL· GenBank· DDBJ
AKQ05948.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271786
EMBL· GenBank· DDBJ
AKQ05949.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271787
EMBL· GenBank· DDBJ
AKQ05950.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271788
EMBL· GenBank· DDBJ
AKQ05951.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271789
EMBL· GenBank· DDBJ
AKQ05952.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271790
EMBL· GenBank· DDBJ
AKQ05953.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271791
EMBL· GenBank· DDBJ
AKQ05954.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271792
EMBL· GenBank· DDBJ
AKQ05955.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271793
EMBL· GenBank· DDBJ
AKQ05956.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271794
EMBL· GenBank· DDBJ
AKQ05957.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271795
EMBL· GenBank· DDBJ
AKQ05958.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271796
EMBL· GenBank· DDBJ
AKQ05959.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271797
EMBL· GenBank· DDBJ
AKQ05960.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271798
EMBL· GenBank· DDBJ
AKQ05961.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271799
EMBL· GenBank· DDBJ
AKQ05962.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271800
EMBL· GenBank· DDBJ
AKQ05963.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271801
EMBL· GenBank· DDBJ
AKQ05964.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271802
EMBL· GenBank· DDBJ
AKQ05965.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271803
EMBL· GenBank· DDBJ
AKQ05966.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271804
EMBL· GenBank· DDBJ
AKQ05967.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271805
EMBL· GenBank· DDBJ
AKQ05968.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271806
EMBL· GenBank· DDBJ
AKQ05969.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271807
EMBL· GenBank· DDBJ
AKQ05970.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271808
EMBL· GenBank· DDBJ
AKQ05971.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271809
EMBL· GenBank· DDBJ
AKQ05972.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271810
EMBL· GenBank· DDBJ
AKQ05973.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271811
EMBL· GenBank· DDBJ
AKQ05974.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271812
EMBL· GenBank· DDBJ
AKQ05975.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271813
EMBL· GenBank· DDBJ
AKQ05976.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271814
EMBL· GenBank· DDBJ
AKQ05977.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271815
EMBL· GenBank· DDBJ
AKQ05978.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271816
EMBL· GenBank· DDBJ
AKQ05979.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271817
EMBL· GenBank· DDBJ
AKQ05980.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271818
EMBL· GenBank· DDBJ
AKQ05981.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271819
EMBL· GenBank· DDBJ
AKQ05982.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271820
EMBL· GenBank· DDBJ
AKQ05983.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271821
EMBL· GenBank· DDBJ
AKQ05984.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271822
EMBL· GenBank· DDBJ
AKQ05985.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271823
EMBL· GenBank· DDBJ
AKQ05986.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271824
EMBL· GenBank· DDBJ
AKQ05987.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271825
EMBL· GenBank· DDBJ
AKQ05988.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271826
EMBL· GenBank· DDBJ
AKQ05989.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271827
EMBL· GenBank· DDBJ
AKQ05990.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271828
EMBL· GenBank· DDBJ
AKQ05991.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271829
EMBL· GenBank· DDBJ
AKQ05992.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271830
EMBL· GenBank· DDBJ
AKQ05993.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271831
EMBL· GenBank· DDBJ
AKQ05994.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271832
EMBL· GenBank· DDBJ
AKQ05995.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271833
EMBL· GenBank· DDBJ
AKQ05996.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271834
EMBL· GenBank· DDBJ
AKQ05997.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271835
EMBL· GenBank· DDBJ
AKQ05998.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271836
EMBL· GenBank· DDBJ
AKQ05999.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271837
EMBL· GenBank· DDBJ
AKQ06000.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271838
EMBL· GenBank· DDBJ
AKQ06001.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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