C1IQ78 · C1IQ78_XESMU
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids181 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Porifera > Demospongiae > Heteroscleromorpha > Haplosclerida > Petrosiidae > Xestospongia
Accessions
- Primary accessionC1IQ78
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-41 | Helical | ||||
Sequence: YLGMVYAMVSIGILGFIVWAHH | ||||||
Transmembrane | 53-76 | Helical | ||||
Sequence: AYFTAATMIIAVPTGIKIFSWVAT | ||||||
Transmembrane | 88-109 | Helical | ||||
Sequence: MLWAVGFVFLFTIGGLTGIVLA | ||||||
Transmembrane | 121-146 | Helical | ||||
Sequence: YYVVAHFHYVLSMGAVFAIFGGFYYW | ||||||
Transmembrane | 158-176 | Helical | ||||
Sequence: VYGKIHFWLMFIGVNLTFF |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-181 | Cytochrome oxidase subunit I profile | ||||
Sequence: FGMISQIIPTFAAKKQIFGYLGMVYAMVSIGILGFIVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKIFSWVATIFGGSLRLDTPMLWAVGFVFLFTIGGLTGIVLANSSLDVVLHDTYYVVAHFHYVLSMGAVFAIFGGFYYWFGKISGYCYNEVYGKIHFWLMFIGVNLTFFPQHFL |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length181
- Mass (Da)20,303
- Last updated2009-05-26 v1
- ChecksumF0D9BE721A5FD9D4
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: F | ||||||
Non-terminal residue | 181 | |||||
Sequence: L |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU716652 EMBL· GenBank· DDBJ | ACH88443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU716653 EMBL· GenBank· DDBJ | ACH88444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU716654 EMBL· GenBank· DDBJ | ACH88445.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271771 EMBL· GenBank· DDBJ | AKQ05934.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271772 EMBL· GenBank· DDBJ | AKQ05935.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271773 EMBL· GenBank· DDBJ | AKQ05936.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271774 EMBL· GenBank· DDBJ | AKQ05937.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271775 EMBL· GenBank· DDBJ | AKQ05938.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271776 EMBL· GenBank· DDBJ | AKQ05939.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271777 EMBL· GenBank· DDBJ | AKQ05940.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271778 EMBL· GenBank· DDBJ | AKQ05941.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271779 EMBL· GenBank· DDBJ | AKQ05942.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271780 EMBL· GenBank· DDBJ | AKQ05943.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271781 EMBL· GenBank· DDBJ | AKQ05944.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271782 EMBL· GenBank· DDBJ | AKQ05945.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271783 EMBL· GenBank· DDBJ | AKQ05946.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271784 EMBL· GenBank· DDBJ | AKQ05947.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271785 EMBL· GenBank· DDBJ | AKQ05948.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271786 EMBL· GenBank· DDBJ | AKQ05949.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271787 EMBL· GenBank· DDBJ | AKQ05950.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271788 EMBL· GenBank· DDBJ | AKQ05951.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271789 EMBL· GenBank· DDBJ | AKQ05952.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271790 EMBL· GenBank· DDBJ | AKQ05953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271791 EMBL· GenBank· DDBJ | AKQ05954.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271792 EMBL· GenBank· DDBJ | AKQ05955.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271793 EMBL· GenBank· DDBJ | AKQ05956.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271794 EMBL· GenBank· DDBJ | AKQ05957.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271795 EMBL· GenBank· DDBJ | AKQ05958.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271796 EMBL· GenBank· DDBJ | AKQ05959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271797 EMBL· GenBank· DDBJ | AKQ05960.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271798 EMBL· GenBank· DDBJ | AKQ05961.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271799 EMBL· GenBank· DDBJ | AKQ05962.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271800 EMBL· GenBank· DDBJ | AKQ05963.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271801 EMBL· GenBank· DDBJ | AKQ05964.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271802 EMBL· GenBank· DDBJ | AKQ05965.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271803 EMBL· GenBank· DDBJ | AKQ05966.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271804 EMBL· GenBank· DDBJ | AKQ05967.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271805 EMBL· GenBank· DDBJ | AKQ05968.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271806 EMBL· GenBank· DDBJ | AKQ05969.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271807 EMBL· GenBank· DDBJ | AKQ05970.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271808 EMBL· GenBank· DDBJ | AKQ05971.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271809 EMBL· GenBank· DDBJ | AKQ05972.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271810 EMBL· GenBank· DDBJ | AKQ05973.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271811 EMBL· GenBank· DDBJ | AKQ05974.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271812 EMBL· GenBank· DDBJ | AKQ05975.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271813 EMBL· GenBank· DDBJ | AKQ05976.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271814 EMBL· GenBank· DDBJ | AKQ05977.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271815 EMBL· GenBank· DDBJ | AKQ05978.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271816 EMBL· GenBank· DDBJ | AKQ05979.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271817 EMBL· GenBank· DDBJ | AKQ05980.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271818 EMBL· GenBank· DDBJ | AKQ05981.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271819 EMBL· GenBank· DDBJ | AKQ05982.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271820 EMBL· GenBank· DDBJ | AKQ05983.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271821 EMBL· GenBank· DDBJ | AKQ05984.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271822 EMBL· GenBank· DDBJ | AKQ05985.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271823 EMBL· GenBank· DDBJ | AKQ05986.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271824 EMBL· GenBank· DDBJ | AKQ05987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271825 EMBL· GenBank· DDBJ | AKQ05988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271826 EMBL· GenBank· DDBJ | AKQ05989.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271827 EMBL· GenBank· DDBJ | AKQ05990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271828 EMBL· GenBank· DDBJ | AKQ05991.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271829 EMBL· GenBank· DDBJ | AKQ05992.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271830 EMBL· GenBank· DDBJ | AKQ05993.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271831 EMBL· GenBank· DDBJ | AKQ05994.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271832 EMBL· GenBank· DDBJ | AKQ05995.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271833 EMBL· GenBank· DDBJ | AKQ05996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271834 EMBL· GenBank· DDBJ | AKQ05997.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271835 EMBL· GenBank· DDBJ | AKQ05998.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271836 EMBL· GenBank· DDBJ | AKQ05999.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271837 EMBL· GenBank· DDBJ | AKQ06000.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT271838 EMBL· GenBank· DDBJ | AKQ06001.1 EMBL· GenBank· DDBJ | Genomic DNA |