C1FUH7 · P47_CLOBJ
- ProteinProtein P47
- Genep47
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids416 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Part of a botulinum neurotoxin type A2 (BoNT) locus; may be part of a progenitor toxin complex required to protect BoNT during its passage through the host gastrointestinal tract.
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein P47
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium
Accessions
- Primary accessionC1FUH7
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000457883 | 1-416 | Protein P47 | |||
Sequence: MNTYGWDIVYGCSKRVVNKHLKEYITKNNIQFLYSNIDKKQEIKMVFDNWEIINGGSSNFLRIKTPIKEGYFKVRNTTVDLSGINPVLEIKLDFFNDISNPNIKELKFNFGSESNDDIKIIVSDLNGNLQEEDEFYFNKLLINAFIQNEKQISYIFASLNVTSDIEWMNPKQFKFVYYSPTDNSDGYLFILSVVTNRDISKLSANVDGNILGNNSEVGLLISEKLFLQNMVLSRLSSNMGSNINKNNFEVISTSDTTGRIVNNSTLNWYGLKVAALYYYPKINNFSMQLFEGNKLKISLRGLVRLTGLEAVYSDFEIQSINKFVYNSTNKKAYFEVDKNPTSSYKYHLFPGDLISLAVLSSVTHWSIKSIEGALGFELINNFVDLINNTIKWNNLKISQVTNVTLNVGFCIQGNAN |
Expression
Induction
Interaction
Subunit
Part of a crude toxin extract that includes BoNTA2/NTNH, P47, OrfX2 and OrfX3; OrfX1 was not detected.
Structure
Family & Domains
Domain
An elongated protein with a middle beta-sheet wrapped around a long alpha-helix. Structurally similar to tubular lipid-binding (TULIP) superfamily proteins. The N-terminal domain (residues 35-175) folds very similarly to OrfX2 (residues 6-168), another protein of the same locus (PubMed:29067689).
This structure is very similar to OrfX3 in the OrfX1-OrfX3 complex from P.bifermentans (AC A0A5P3XKL3, PDB:8BGM).
This structure is very similar to OrfX3 in the OrfX1-OrfX3 complex from P.bifermentans (AC A0A5P3XKL3, PDB:8BGM).
Sequence similarities
Belongs to the TULIP P47 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length416
- Mass (Da)47,476
- Last updated2009-05-26 v1
- Checksum749EB3877C4A9D2E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001581 EMBL· GenBank· DDBJ | ACO84705.1 EMBL· GenBank· DDBJ | Genomic DNA |