C1D5K2 · SECA_LARHH
- ProteinProtein translocase subunit SecA
- GenesecA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids906 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Catalytic activity
Cofactor
Note: May bind 1 zinc ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 87 | ATP (UniProtKB | ChEBI) | |||
Binding site | 105-109 | ATP (UniProtKB | ChEBI) | |||
Binding site | 507 | ATP (UniProtKB | ChEBI) | |||
Binding site | 890 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 892 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 901 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 902 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell envelope Sec protein transport complex | |
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein-exporting ATPase activity | |
Biological Process | intracellular protein transmembrane transport | |
Biological Process | protein import | |
Biological Process | protein targeting | |
Biological Process | protein transport by the Sec complex |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein translocase subunit SecA
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Aquaspirillaceae > Laribacter
Accessions
- Primary accessionC1D5K2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Peripheral membrane protein
Note: Distribution is 50-50.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000184234 | 1-906 | Protein translocase subunit SecA | ||
Interaction
Subunit
Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length906
- Mass (Da)101,119
- Last updated2009-05-26 v1
- ChecksumE9BBD672BC1FC6DC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001154 EMBL· GenBank· DDBJ | ACO76019.1 EMBL· GenBank· DDBJ | Genomic DNA |