C1D1Q9 · TILS_DEIDV
- ProteintRNA(Ile)-lysidine synthase
- GenetilS
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids533 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
Catalytic activity
- cytidine34 in tRNA(Ile2) + L-lysine + ATP = lysidine34 in tRNA(Ile2) + AMP + diphosphate + H+
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | tRNA(Ile)-lysidine synthase activity | |
Molecular Function | tRNA-specific adenosine-34 deaminase activity | |
Molecular Function | zinc ion binding | |
Biological Process | tRNA wobble adenosine to inosine editing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA(Ile)-lysidine synthase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Deinococcota > Deinococci > Deinococcales > Deinococcaceae > Deinococcus
Accessions
- Primary accessionC1D1Q9
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000213710 | 1-533 | tRNA(Ile)-lysidine synthase | |||
Sequence: MSTLLAPLHPYAGRVVVVGVSGGADSVALLRALVQAEARPVVAHLDHALRPNSAEDAQWVHDLAEQLGAAHTSTRVDVAAVAARRGWNVEDAARRVRYEVLSRAARQHGAHTVMTAHTRRDQAETVLMGLLRGEAVLTGIPAVRGRVRRPWLDVPRSEIEAYLKALGQEWREDPTNADVTYTRAWLRTEVMPVLAARFPGVEAALGRVAKLAQQDDEALRDLAAALTPHAPRDRVPLAVLRRRVTQELKSAGLQFHVGQVDQLAEAQRTGETRHVTLLGGRGVTVTGGALHLAARAWPLPSFSWPEDWTLRTRQPGDRITLPGGTRKVSDVLTDLKIPRDQRDDVPLLVSAQGVKWIGVEPNIWAKGARAVVGQPADLLDTAMGEALGLAREAALAQEVPVGAVVLGPGGRIIGSGRNTSRADSDMTRHAELAALRAATAELGTAYLTGCTLVVTLEPCPMCLGAALEARVERIVYGASNPKAGALGGVSDLLSSHWGHVPAVTGGVRAQDAARVLRDSFQELRQRRLKSPDV |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 377-500 | CMP/dCMP-type deaminase | ||||
Sequence: DLLDTAMGEALGLAREAALAQEVPVGAVVLGPGGRIIGSGRNTSRADSDMTRHAELAALRAATAELGTAYLTGCTLVVTLEPCPMCLGAALEARVERIVYGASNPKAGALGGVSDLLSSHWGHV |
Domain
The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.
Sequence similarities
Belongs to the tRNA(Ile)-lysidine synthase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length533
- Mass (Da)57,183
- Last updated2009-05-26 v1
- Checksum88B615B2B0F0AD71
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001114 EMBL· GenBank· DDBJ | ACO45783.1 EMBL· GenBank· DDBJ | Genomic DNA |