C1D1Q9 · TILS_DEIDV

Function

function

Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.

Catalytic activity

Features

Showing features for binding site.

153350100150200250300350400450500
TypeIDPosition(s)Description
Binding site21-26ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctiontRNA(Ile)-lysidine synthase activity
Molecular FunctiontRNA-specific adenosine-34 deaminase activity
Molecular Functionzinc ion binding
Biological ProcesstRNA wobble adenosine to inosine editing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA(Ile)-lysidine synthase
  • EC number
  • Alternative names
    • tRNA(Ile)-2-lysyl-cytidine synthase
    • tRNA(Ile)-lysidine synthetase

Gene names

    • Name
      tilS
    • Ordered locus names
      Deide_09052

Organism names

Accessions

  • Primary accession
    C1D1Q9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002137101-533tRNA(Ile)-lysidine synthase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain377-500CMP/dCMP-type deaminase

Domain

The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

Sequence similarities

Belongs to the tRNA(Ile)-lysidine synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    533
  • Mass (Da)
    57,183
  • Last updated
    2009-05-26 v1
  • Checksum
    88B615B2B0F0AD71
MSTLLAPLHPYAGRVVVVGVSGGADSVALLRALVQAEARPVVAHLDHALRPNSAEDAQWVHDLAEQLGAAHTSTRVDVAAVAARRGWNVEDAARRVRYEVLSRAARQHGAHTVMTAHTRRDQAETVLMGLLRGEAVLTGIPAVRGRVRRPWLDVPRSEIEAYLKALGQEWREDPTNADVTYTRAWLRTEVMPVLAARFPGVEAALGRVAKLAQQDDEALRDLAAALTPHAPRDRVPLAVLRRRVTQELKSAGLQFHVGQVDQLAEAQRTGETRHVTLLGGRGVTVTGGALHLAARAWPLPSFSWPEDWTLRTRQPGDRITLPGGTRKVSDVLTDLKIPRDQRDDVPLLVSAQGVKWIGVEPNIWAKGARAVVGQPADLLDTAMGEALGLAREAALAQEVPVGAVVLGPGGRIIGSGRNTSRADSDMTRHAELAALRAATAELGTAYLTGCTLVVTLEPCPMCLGAALEARVERIVYGASNPKAGALGGVSDLLSSHWGHVPAVTGGVRAQDAARVLRDSFQELRQRRLKSPDV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001114
EMBL· GenBank· DDBJ
ACO45783.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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