C1BYA3 · MTNB_ESOLU

  • Protein
    Methylthioribulose-1-phosphate dehydratase
  • Gene
    apip
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site107substrate
Binding site125Zn2+ (UniProtKB | ChEBI)
Binding site127Zn2+ (UniProtKB | ChEBI)
Active site149Proton donor/acceptor
Binding site205Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmethylthioribulose 1-phosphate dehydratase activity
Molecular Functionzinc ion binding
Biological Processapoptotic process
Biological ProcessL-methionine salvage from methylthioadenosine
Biological ProcessL-methionine salvage from S-adenosylmethionine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylthioribulose-1-phosphate dehydratase
  • EC number
  • Short names
    MTRu-1-P dehydratase
  • Alternative names
    • APAF1-interacting protein homolog

Gene names

    • Name
      apip

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Esociformes > Esocidae > Esox

Accessions

  • Primary accession
    C1BYA3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003937731-257Methylthioribulose-1-phosphate dehydratase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-33Disordered
Compositional bias12-33Basic and acidic residues

Sequence similarities

Belongs to the aldolase class II family. MtnB subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    257
  • Mass (Da)
    29,383
  • Last updated
    2009-05-26 v1
  • Checksum
    B98A2114037151DF
MVSSQEKMASISDIIQKDEDSGSEKTESQDKEHPRVLIPELCRLFYKLGWVTGTGGGISLRHGDQIYIAPSGVQKERLQPEDMFVCDVEERDICVPPAWKNLKKGQCTPLFMNAYTMRAAQAVIHTHSKAAVMATLFYPGKEFRITHQEMIKGIRKCTSGTNYRYDETLVVPIIENTPEEQDLKERMALAMEQYPESCAVLVRRHGVYVWGESWEKAKTMCECYDYLFDIAVKMKQCGLDPSAQPVEENLYYYVQQA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias12-33Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BT079582
EMBL· GenBank· DDBJ
ACO14006.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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