C1AYB4 · HOA5_RHOOB
- Protein4-hydroxy-2-oxovalerate aldolase 5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids352 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- (S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate
Features
Showing features for site, binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 17 | Transition state stabilizer | |||
Binding site | 17-18 | substrate | |||
Binding site | 18 | Mn2+ (UniProtKB | ChEBI) | |||
Active site | 21 | Proton acceptor | |||
Binding site | 171 | substrate | |||
Binding site | 200 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 200 | substrate | |||
Binding site | 202 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 291 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-isopropylmalate synthase activity | |
Molecular Function | 4-hydroxy-2-oxovalerate aldolase activity | |
Molecular Function | manganese ion binding | |
Biological Process | catabolic process | |
Biological Process | L-leucine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-2-oxovalerate aldolase 5
- EC number
- Short namesHOA 5
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Nocardiaceae > Rhodococcus
Accessions
- Primary accessionC1AYB4
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000387896 | 1-352 | 4-hydroxy-2-oxovalerate aldolase 5 | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 9-261 | Pyruvate carboxyltransferase | |||
Sequence similarities
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length352
- Mass (Da)36,903
- Last updated2009-05-26 v1
- Checksum2EF12C5AFAC85F59
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP011115 EMBL· GenBank· DDBJ | BAH54109.1 EMBL· GenBank· DDBJ | Genomic DNA |