C1AUL1 · CYSH_RHOOB

Function

function

Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site133[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site134[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site216[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site219[4Fe-4S] cluster (UniProtKB | ChEBI)
Active site242Nucleophile; cysteine thiosulfonate intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionadenylyl-sulfate reductase (thioredoxin) activity
Molecular Functionmetal ion binding
Molecular Functionphosphoadenylyl-sulfate reductase (thioredoxin) activity
Biological Processcysteine biosynthetic process
Biological Processsulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosine 5'-phosphosulfate reductase
  • EC number
  • Short names
    APS reductase
  • Alternative names
    • 5'-adenylylsulfate reductase
    • Thioredoxin-dependent 5'-adenylylsulfate reductase

Gene names

    • Name
      cysH
    • Ordered locus names
      ROP_09720

Organism names

Accessions

  • Primary accession
    C1AUL1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001179311-247Adenosine 5'-phosphosulfate reductase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region222-247Disordered

Sequence similarities

Belongs to the PAPS reductase family. CysH subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    247
  • Mass (Da)
    26,281
  • Last updated
    2009-05-26 v1
  • Checksum
    CE003F53096FA310
MSVDLSSATEGDLRELAARGAASLEGASARELLQWTEETFGSGASEGTGYRNSFIVASNMQDGVLVHLAAQVHPGVDVLFLDTGYHFAETIGTRDAVEQVYGVNVINARAEASVAEQDAAEGKDLFAREPNRCCALRKVAPLKKTLAGYKAWVTGIRRVEAPTRANAPLISFDDAFGLVKINPIAAWSDEDMQSYIDEHSILVNPLVDEGYPSIGCAPCTSKPAPGSDPRSGRWAGQAKTECGLHAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP011115
EMBL· GenBank· DDBJ
BAH49219.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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