C1ATY7 · HIS6_RHOOB
- ProteinImidazole glycerol phosphate synthase subunit HisF
- GenehisF
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids257 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Catalytic activity
- 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H+ + L-glutamate
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 12 | |||||
Sequence: D | ||||||
Active site | 131 | |||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | imidazoleglycerol-phosphate synthase activity | |
Molecular Function | lyase activity | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameImidazole glycerol phosphate synthase subunit HisF
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Nocardiaceae > Rhodococcus
Accessions
- Primary accessionC1ATY7
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000148936 | 1-257 | Imidazole glycerol phosphate synthase subunit HisF | |||
Sequence: MTLAVRVIPCLDVDAGRVVKGVNFENLRDAGDPVELAAAYDAQGADELTFLDVTASTADRGTMLDVVSRTAEQVFIPLTVGGGVRTVEDVDRLLRAGADKVSVNTAAIARPELLRELSERFGSQCIVLSVDARTVPQGQPDTPSGWEVTTHGGKRGTGIDAVEWAVRGAELGVGEILLNSMDADGTKAGFDLPMIRAVRAAVHVPVIASGGAGAVEHFAPAVGAGADAVLAASVFHFGDMTIGDVKKSMRAEGITVR |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length257
- Mass (Da)26,688
- Last updated2009-05-26 v1
- Checksum3889EF4DFE2BD8C0
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP011115 EMBL· GenBank· DDBJ | BAH48995.1 EMBL· GenBank· DDBJ | Genomic DNA |