C1ASQ7 · HIS1_RHOOB
- ProteinATP phosphoribosyltransferase
- GenehisG
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids283 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Catalytic activity
- 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
Cofactor
Activity regulation
Feedback inhibited by histidine.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP phosphoribosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP phosphoribosyltransferase
- EC number
- Short namesATP-PRT ; ATP-PRTase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Nocardiaceae > Rhodococcus
Accessions
- Primary accessionC1ASQ7
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000118256 | 1-283 | ATP phosphoribosyltransferase | |||
Sequence: MLRVAVPNKGSLSESAAEILSEAGYRRRTDSRDLTVLDPSNQVEFFFLRPKDIAIYVGSGELDLGITGRDLARDSGAPVAERLSLGFGRSTFRYAAPAGKDWKVEDLAGLRIATSYPNLVRDDLSARGIEASVIRLDGAVEISIQLGVADAIADVVGSGRTLRQHNLVAFGDTLCDSEGVLIERAGSPADDSARNQLVERVRGIVFAQQNLMLDYDCPKTILDDALKITPGLESPTLSPLADENWVAVRAMVPIKGHNGVMDELADLGAKAILASNIRSCRAL |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length283
- Mass (Da)30,374
- Last updated2009-05-26 v1
- Checksum457F79A64A252D96
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP011115 EMBL· GenBank· DDBJ | BAH48839.1 EMBL· GenBank· DDBJ | Genomic DNA |