C0ZUD4 · FGD_RHOE4
- ProteinF420-dependent glucose-6-phosphate dehydrogenase
- Genefgd
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids337 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone.
Catalytic activity
- D-glucose 6-phosphate + H+ + oxidized coenzyme F420-(gamma-L-Glu)(n) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)
CHEBI:61548 + CHEBI:15378 + oxidized coenzyme F420-(γ-L-Glu)(n) RHEA-COMP:12939 = CHEBI:57955 + reduced coenzyme F420-(γ-L-Glu)(n) RHEA-COMP:14378
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 40 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 41 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 77 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 108-109 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: SG | ||||||
Active site | 110 | Proton acceptor | ||||
Sequence: E | ||||||
Binding site | 113 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 178-179 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: GG | ||||||
Binding site | 181-182 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: VV | ||||||
Binding site | 196 | substrate | ||||
Sequence: T | ||||||
Binding site | 199 | substrate | ||||
Sequence: K | ||||||
Binding site | 260 | substrate | ||||
Sequence: K | ||||||
Binding site | 284 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | coenzyme F420 binding | |
Molecular Function | glucose-6-phosphate dehydrogenase (coenzyme F420) activity | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
Biological Process | carbohydrate metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameF420-dependent glucose-6-phosphate dehydrogenase
- EC number
- Short namesFGD ; G6PD
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Nocardiaceae > Rhodococcus > Rhodococcus erythropolis group
Accessions
- Primary accessionC0ZUD4
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000413600 | 1-337 | F420-dependent glucose-6-phosphate dehydrogenase | |||
Sequence: MAQELKLGYKASAEQFGPRELVELAVLAEQHGMDSVAVSDHFQPWRHNGGHAPFSLAWMTAVGERTERVQIGTSVMTPTFRYNPAVIAQAFATMGCLYPGRIMLGVGSGEALNEIATGFQGEWPEFKERFARLRESVRLMRELWLGDRVDFEGEYFTTRGASIYDVPEGGIPVYIAAGGPVVARYAGRAGDGFICTSGKGMELYTEKLLPAVAEGAAKAERDVADIDKMIEIKISYDTDPEAALENTRFWAPLSLTPEQKHSIEDPIEMEAAADALPIEQVAKRWIVASDPDDAVEQVKAYVDAGLNHLVFHAPGHDQRRFLELFERDLAPRLRALG |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length337
- Mass (Da)37,197
- Last updated2009-05-26 v1
- Checksum47618A57C57ACD5E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP008957 EMBL· GenBank· DDBJ | BAH32179.1 EMBL· GenBank· DDBJ | Genomic DNA |