C0Z9X2 · CYSI_BREBN

Function

function

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
siroheme (UniProtKB | Rhea| CHEBI:60052 )

Note: Binds 1 siroheme per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site438[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site444[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site483[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site487[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site487Fe (UniProtKB | ChEBI) of siroheme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentsulfite reductase complex (NADPH)
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Molecular Functionsulfite reductase (NADPH) activity
Biological Processcysteine biosynthetic process
Biological Processhydrogen sulfide biosynthetic process
Biological Processsulfate assimilation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sulfite reductase [NADPH] hemoprotein beta-component
  • EC number
  • Short names
    SiR-HP
    ; SiRHP

Gene names

    • Name
      cysI
    • Ordered locus names
      BBR47_58490

Organism names

Accessions

  • Primary accession
    C0Z9X2

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003884801-573Sulfite reductase [NADPH] hemoprotein beta-component

Interaction

Subunit

Alpha8-beta8. The alpha component is a flavoprotein, the beta component is a hemoprotein.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-21Disordered

Sequence similarities

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    573
  • Mass (Da)
    65,399
  • Last updated
    2009-05-26 v1
  • Checksum
    BF0EEBBFB44E748C
MSENHLLSSNSAPHSDVEDIKRKSDYLRGSLAETLEDRISGSIPEDDNRLMKFHGSYMQDDRDLRNERSKQKLEPAYQFMVRVRAAGGVVTPEQWLMMDDIAQQFANGTIRLTTRQSFQLHGVIKWNMKQVIQEVNEALLSTLAACGDVNRNVMCNPNPYESEVHQEVYEWAKKISNHLDPRTRAYHEIWLDEEKVVDSRDEVEQEPIYGPVYLPRKFKIGIAVPPANDVDVFSQDLGFIAIHEEGRLLGFNVAVGGGMGMTHGDPKTYPQVARVIGFVTPEQVLEVAEKTVMIQRDYGDRAVRKHARFKYTIDDRGIEWFIHELEQRLGWELEQVRPYHFEHNGDRYGWVKGSDDNWHFTLFIQNGRVKDEDNYLLKSGLREIAKVHTGDFRLTPNQNLLIGNVTSEKKPEIEQIIQAYGLTDGATYSALRRNSMACVSLPTCGLAMAEAERYLPTLLDEIELILDEAGLRDEEIVIRMTGCPNGCARPALAEISFIGKAVGKYNMYLGGGFSGNRLNKLYRENIGEAEILNELRPILNRYAKEREEGEHFGDFVIRAGYVKEVRSGLDFHE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP008955
EMBL· GenBank· DDBJ
BAH46826.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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