C0XLR9 · C0XLR9_LENH9

Function

function

Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
    EC:3.1.21.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site85Mg2+ (UniProtKB | ChEBI)
Binding site87Mg2+ (UniProtKB | ChEBI)
Binding site100Mg2+ (UniProtKB | ChEBI)
Site102Transition state stabilizer
Binding site119Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionendonuclease activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleic acid binding
Biological Processchromosome segregation
Biological ProcessDNA recombination
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Holliday junction resolvase RecU
  • EC number
  • Alternative names
    • Recombination protein U homolog

Gene names

    • Name
      recU
    • ORF names
      HMPREF0519_2209

Organism names

Accessions

  • Primary accession
    C0XLR9

Proteomes

Subcellular Location

Keywords

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-24Disordered

Sequence similarities

Belongs to the RecU family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    199
  • Mass (Da)
    23,166
  • Last updated
    2009-05-26 v1
  • Checksum
    638FFC20F70B576C
MTIKYPDGHQFHRQSGFEQSHNDSIDFSNRGMTLEAELNESNKFYLNNEIAVIHKKPTPIQIVSVDYPKRSAARIKEAYFRRASTTDYNGVYQGHYIDFDAKETKNKTSFPLKNFHKHQVEHMRECLKQRGICFAIIKFVNDQSVFLLKATDLIDYWDQQQVGGRKSIPRKTIEEIGVAVPYQINPLLPYLRAVDLIIE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACGP01000184
EMBL· GenBank· DDBJ
EEI23682.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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