TGF-beta1 promotes epithelial-to-mesenchymal transition and stemness of prostate cancer cells by inducing PCBP1 degradation and alternative splicing of CD44.
CD44 Gene Polymorphisms as a Risk Factor for Susceptibility and Their Effect on the Clinicopathological Characteristics of Lung Adenocarcinoma in Male Patients.
Reports indicate that high CD44 expression in ascites tumor cells (ATC) correlates with CSC and EMT phenotype both regulated by the tumor microenvironment through several signaling pathways including the TGF-beta signaling pathway.
Osteopontin and CD44 play important roles in the development and progression of meningioma and can be used as prognostic markers for tumor recurrence and progression as well as therapeutic targets for the development of new drugs.
Malignant transformation of mucinous tumors is associated with changes in CD44 expression with low expression level being a prognostic factor in ovarian mucinous carcinomas.
CD133(+) CD44(+) CD54(+) cellular subpopulation of circulating tumor cells has a prognostic value in colorectal cancer patients with liver metastasis especially in the survival of CRC patients with liver metastasis who did not undergo surgical treatment for metastasis.
based on our data the markers CD44 and CD24 do not reflect the features of CSC and unfavorable prognosis and do not clarify the role and clinical significance of the immunophenotype CD44+/CD24-.
CNS disease was associated with enhanced expression of cytoplasmic and membranous ITGA10 and nuclear PTEN (P < 0.0005 P = 0.002 P = 0.024 respectively). sCNSL presented decreased membranous CD44 and nuclear and cytoplasmic cadherin-11 expressions (P = 0.001 P = 0.006 P = 0.048 respectively). In PCNSL lactoferrin expression was upregulated (P < 0.0005).
The rates of CD44st and MMP2 expression were higher in squamous cell carcinomas than in adenocarcinomas were closely associated with lymph node metastasis and TNM stage and affected patients' prognoses.
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