C0SP85 · YUKE_BACSU

Function

function

Required to deliver LXG toxins to target cells.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein YukE

Gene names

    • Name
      yukE
    • Ordered locus names
      BSU31910

Organism names

Accessions

  • Primary accession
    C0SP85
  • Secondary accessions
    • P71072
    • Q795L2

Proteomes

Subcellular Location

Secreted
Note: Secreted via the ESX/ESAT-6-like secretion system (BsEss) / type VII secretion system (T7SS) (PubMed:23861817, PubMed:24798022).
Can be secreted as a dimer (PubMed:24828531).

Keywords

Phenotypes & Variants

Disruption phenotype

Cells lacking this gene display an increased bacteriophage SPP1 resistance phenotype (PubMed:15576783).
Loss of delivery of LXG type toxins to target cells (PubMed:34280190).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis44Lack of secretion, but does not affect dimerization.
Mutagenesis44Lack of secretion.
Mutagenesis44Strong decrease in secretion.
Mutagenesis45Does not affect secretion and dimerization.
Mutagenesis45Does not affect secretion.
Mutagenesis45Strong decrease in secretion.
Mutagenesis46Lack of secretion, but does not affect dimerization.
Mutagenesis46Lack of secretion.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003836351-97Protein YukE

Proteomic databases

Expression

Induction

Positively regulated by phosphorylated DegU.

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil21-94

Domain

The WXG motif and the C-terminal tail are crucial for secretion.

Sequence similarities

Belongs to the WXG100 family. sagEsxA-like subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    97
  • Mass (Da)
    10,993
  • Last updated
    2009-05-05 v1
  • Checksum
    C36A9624626BA4C3
MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMWEGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG

Sequence caution

The sequence CAB04773.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence CAB04773.1 differs from that shown. Reason: Frameshift

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z82015
EMBL· GenBank· DDBJ
CAB04773.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL009126
EMBL· GenBank· DDBJ
CAB15179.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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