C0QVC0 · GLPK_BRAHW
- ProteinGlycerol kinase
- GeneglpK
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids494 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
Catalytic activity
- ATP + glycerol = ADP + H+ + sn-glycerol 3-phosphate
Activity regulation
Inhibited by fructose 1,6-bisphosphate (FBP).
Pathway
Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 12 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 12 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 12 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 13 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 14 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 16 | ADP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 82 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 82 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 83 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 83 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 134 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 134 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 241 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 241 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 242 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 263 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 263 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 306 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 306 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 310 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 407 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 407 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | glycerol kinase activity | |
Biological Process | glycerol catabolic process | |
Biological Process | glycerol metabolic process | |
Biological Process | glycerol-3-phosphate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Spirochaetota > Spirochaetia > Brachyspirales > Brachyspiraceae > Brachyspira
Accessions
- Primary accessionC0QVC0
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000124183 | 1-494 | Glycerol kinase | |||
Sequence: MAKYVVAIDQGTTSSRAIVFDYDQNMVSVAQKEFTQIYPHEGWVEHNAAEIWATQFGVLQEAIQIAGVKPEEIAAIGITNQRETTVVWDKNTGEPIYNAIVWQCRRTAPICDELKKKGLDTYIRENTGLVVDAYFSGTKIKWILDNVPGAREKANKGELLFGTIDTWLVWKLTGGKVHVTDYTNASRTMIYNIKELKWDETILKELDIPMSMLPEVKDSSCIYGYAHINGKEVPISGIAGDQQSALFGQAGFNKGDTKNTYGTGSFILMNIGENFILSKNGLITTIAIGYNGKIEYALEGSVFIAGAVIQWVRDELRLLHDAKDTEYFATKVKDTNGVYLVPAFVGLGAPYWDMYARGCLVGITRGVNRSHIIRAAEEAIAYQSKDVIDAMVADSGVKLSSLKVDGGACRDNFLMQFQSDIINTKVLRPQITETTALGAAYLAGLAVGFWKDKDEITNRWKLEREFTPSLSEEERNKKYMGWKKAVERSRGWAL |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length494
- Mass (Da)55,087
- Last updated2009-05-05 v1
- Checksum83C377F6F95068A8
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001357 EMBL· GenBank· DDBJ | ACN84421.1 EMBL· GenBank· DDBJ | Genomic DNA |