C0P9J6 · ADH1A_MAIZE

  • Protein
    Aminoaldehyde dehydrogenase 1a
  • Gene
    AMADH1A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Dehydrogenase that catalyzes the oxidation of several aminoaldehydes (PubMed:23408433).
Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively (PubMed:23408433).
Catalyzes the oxidation of 4-(trimethylamino)butanal and 4-guanidinobutanal to 4-trimethylammoniobutanoate and 4-guanidinobutanoate, respectively (PubMed:23408433).
Catalyzes the oxidation of betaine aldehyde to glycine betaine (PubMed:23408433).
Dehydrogenase that catalyzes the oxidation of several aminoaldehydes (PubMed:21740525).
Catalyzes the oxidation of betaine aldehyde to glycine betaine (PubMed:21740525).
Catalyzes the oxidation of 4-(trimethylamino)butanal to 4-trimethylammoniobutanoate (PubMed:21740525).

Catalytic activity

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
28 μM4-aminobutanal
9 μM3-aminopropanal
6 μM4-(trimethylamino)butanal
3 μM4-guanidinobutanal
14 μMbetaine aldehyde
91 μMNAD+ with 3-aminopropanal as substrate
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
11 nmol/sec/mgwith betaine aldehyde as substrate

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site101Na+ (UniProtKB | ChEBI)
Binding site161-163NAD+ (UniProtKB | ChEBI)
Site164Transition state stabilizer
Binding site187-190NAD+ (UniProtKB | ChEBI)
Binding site191Na+ (UniProtKB | ChEBI)
Binding site241-244NAD+ (UniProtKB | ChEBI)
Active site262Proton acceptor
Binding site262NAD+ (UniProtKB | ChEBI)
Active site296Nucleophile
Binding site395NAD+ (UniProtKB | ChEBI)
Binding site461NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-trimethylammoniobutyraldehyde dehydrogenase activity
Molecular Functionaminobutyraldehyde dehydrogenase activity
Molecular Functionbetaine-aldehyde dehydrogenase activity
Molecular Functiongamma-guanidinobutyraldehyde dehydrogenase activity
Molecular Functionnucleotide binding
Molecular Functionprotein homodimerization activity
Molecular Functionsodium ion binding
Biological Processcellular detoxification of aldehyde
Biological Processglycine betaine biosynthetic process from choline

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aminoaldehyde dehydrogenase 1a
  • EC number
  • Short names
    ZmAMADH1a
  • Alternative names
    • 4-trimethylammoniobutyraldehyde dehydrogenase AMADH1a
      (EC:1.2.1.47
      ) . EC:1.2.1.47 (UniProtKB | ENZYME | Rhea)
    • Aminobutyraldehyde dehydrogenase AMADH1a
      (EC:1.2.1.19
      ) . EC:1.2.1.19 (UniProtKB | ENZYME | Rhea)
    • Betaine aldehyde dehydrogenase AMADH1a
      (EC:1.2.1.8
      ) . EC:1.2.1.8 (UniProtKB | ENZYME | Rhea)
    • Gamma-guanidinobutyraldehyde dehydrogenase AMADH1a
      (EC:1.2.1.54
      ) . EC:1.2.1.54 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      AMADH1A
    • Synonyms
      ALDH10A8
    • ORF names
      ZEAMMB73_Zm00001d050339

Organism names

  • Taxonomic identifier
  • Strain
    • cv. B73
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > PACMAD clade > Panicoideae > Andropogonodae > Andropogoneae > Tripsacinae > Zea

Accessions

  • Primary accession
    C0P9J6

Proteomes

Genome annotation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004541351-505Aminoaldehyde dehydrogenase 1a

Expression

Gene expression databases

Interaction

Subunit

Forms homodimers.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    505
  • Mass (Da)
    54,913
  • Last updated
    2009-05-05 v1
  • Checksum
    5B3D693764642D8F
MASPAMVPLRQLFVDGEWRPPAQGRRLPVVNPTTEAHIGEIPAGTAEDVDAAVAAARAALKRNRGRDWARAPGAVRAKYLRAIAAKVIERKPELAKLEALDCGKPYDEAAWDMDDVAGCFEYFADQAEALDKRQNSPVSLPMETFKCHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAVLKPSELASVTCLELADICKEVGLPSGVLNIVTGLGPDAGAPLSAHPDVDKVAFTGSFETGKKIMASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLLIHTKIAKKFNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATILTGGVRPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYGLAGAVISGDRERCQRLSEEIDAGCIWVNCSQPCFCQAPWGGNKRSGFGRELGEGGIDNYLSVKQVTEYISDEPWGWYQSPSKL

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A804NQX3A0A804NQX3_MAIZE100302679393
A0A804NQX4A0A804NQX4_MAIZE100302679413
A0A804NQX5A0A804NQX5_MAIZE100302679476

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ184593
EMBL· GenBank· DDBJ
ACS74867.1
EMBL· GenBank· DDBJ
mRNA
CM000780
EMBL· GenBank· DDBJ
AQK52374.1
EMBL· GenBank· DDBJ
Genomic DNA
BT064965
EMBL· GenBank· DDBJ
ACN30841.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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