C0LJI8 · C0LJI8_9EURY

Function

function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

Catalytic activity

  • ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.
    EC:6.5.1.6 (UniProtKB | ENZYME | Rhea)
  • NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.
    EC:6.5.1.6 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

155950100150200250300350400450500550
TypeIDPosition(s)Description
Binding site247ATP (UniProtKB | ChEBI)
Active site249N6-AMP-lysine intermediate
Binding site254ATP (UniProtKB | ChEBI)
Binding site269ATP (UniProtKB | ChEBI)
Binding site299ATP (UniProtKB | ChEBI)
Binding site339ATP (UniProtKB | ChEBI)
Binding site414ATP (UniProtKB | ChEBI)
Binding site420ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA ligase (ATP) activity
Molecular Functionmetal ion binding
Biological Processcell division
Biological ProcessDNA biosynthetic process
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological ProcessDNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA ligase
  • EC number
  • Alternative names
    • Polydeoxyribonucleotide synthase [ATP/NAD(+)]

Gene names

    • Name
      lig

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 1519
  • Taxonomic lineage
    Archaea > Euryarchaeota > Thermococci > Thermococcales > Thermococcaceae > Thermococcus

Accessions

  • Primary accession
    C0LJI8

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain327-455ATP-dependent DNA ligase family profile

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    559
  • Mass (Da)
    63,521
  • Last updated
    2009-05-05 v1
  • Checksum
    F6B9EB2CB724278A
MKYSELADLYRRLEKTTLKTLKTKFVADFLKKTPDELLEVVPYLILGKVFPDWDERELGVGEKLLIKAVSMATGVPEKEIENSIKDTGDLGESVALALKKRKQKSFFSQPLTIKRVYSTFVKVAEASGEGSQDRKMKYLANLFMDAQPEEGKYIARTVLGTMRTGVAEGILRDAIAEAFRVKPELVERAYMLTSDFGYVAKVAKLEGNEGLSKVSIQIGKPIRPMLAQNAASVKEALIEMGGEAAFEIKYDGARVQVHRDGDRVIIYSRRLENVTRSIPEIVEAVKASLKPSKVIVEGELVAVGENGRPRPFQYVLRRFRRKYNIDEMIEKIPLELNLFDILYVDGESLIDTEFVERRKRLEESVEESEKIKIAEQLVTKKVEEAEAFYKRALELGHEGLMAKRLDSVYEPGNRGKKWLKIKPTMENLDLVIIGAEWGEGRRAHLLGSFLVAAYDPDSGEFLPVGKVGSGFTDEDLVEFTKMLKPLILREEGKFVEIEPKVVIEVTYQEIQKSPKYRSGFALRFPRYVALREDKSPEEADTIERIAQLYELQEKFKAKR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ713107
EMBL· GenBank· DDBJ
ACN59570.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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