C0K3N3 · TXVE_CROAT

Function

function

Snake venom VEGFs that may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension. This protein induces an increase in capillary permeability after intradermal injection, as well as a drastic hypotensive effect after intravenous injection (By similarity).
The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase. Also induces angiogenesis in vitro (By similarity).
Like other crotalid VEGFs, this protein interacts with VEGF receptor-1 (FLT1) with a high affinity, whereas it binds to VEGF receptor-2 (KDR) with a low affinity (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentmembrane
Molecular Functionchemoattractant activity
Molecular Functiongrowth factor activity
Molecular Functiontoxin activity
Molecular Functionvascular endothelial growth factor receptor 1 binding
Biological Processinduction of positive chemotaxis
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of endothelial cell proliferation
Biological Processpositive regulation of mast cell chemotaxis
Biological Processpositive regulation of protein phosphorylation
Biological Processresponse to hypoxia
Biological Processsprouting angiogenesis
Biological Processvascular endothelial growth factor receptor signaling pathway
Biological Processvascular endothelial growth factor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Snake venom vascular endothelial growth factor toxin cratrin
  • Short names
    svVEGF
  • Alternative names
    • VEGF-F

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Viperidae > Crotalinae > Crotalus

Accessions

  • Primary accession
    C0K3N3

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, modified residue, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-24
Modified residue25Pyrrolidone carboxylic acid
ChainPRO_500045206225-144Snake venom vascular endothelial growth factor toxin cratrin
Disulfide bond38↔80
Disulfide bond63Interchain (with C-72)
Disulfide bond69↔115
Disulfide bond72Interchain (with C-63)
Disulfide bond73↔117

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Interaction

Subunit

Homodimer; disulfide-linked. Interacts with VEGF receptor-1 (FLT1) with a high affinity, whereas it binds to VEGF receptor-2 (KDR) with a low affinity. Does not bind VEGF receptor-3 (FLT4).

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias119-137Basic and acidic residues
Region119-144Disordered

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    144
  • Mass (Da)
    16,126
  • Last updated
    2009-05-05 v1
  • Checksum
    49F5197653C92A6E
MAVYLLAVAILFCIQGWPSGTVQGQAMSFMEVYERSVCQTREMLVSILDEYPSEVAHLFRPSCVTVLRCGGCCTDESLTCTATGKRSVGREIMRVDPRKGTSKIEVMQFTEHTECECRPRSTVNNGKRKKNPKEGEPRAKFPLV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias119-137Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ554637
EMBL· GenBank· DDBJ
ACN22040.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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