C0J6Z9 · C0J6Z9_9CARY

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    cox1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 3
    • 4
    • 5
    • 7
    • 11
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Caryophyllaceae > Sileneae > Silene > Silene subgen. Silene > Silene sect. Siphonomorpha

Accessions

  • Primary accession
    C0J6Z9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical
Transmembrane36-63Helical
Transmembrane83-107Helical
Transmembrane119-143Helical
Transmembrane155-178Helical
Transmembrane190-211Helical
Transmembrane231-254Helical
Transmembrane266-288Helical
Transmembrane308-328Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-345Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    345
  • Mass (Da)
    38,154
  • Last updated
    2009-05-05 v1
  • Checksum
    DFA71DE9F0D21819
FSLHLSGVSSILGSINFITTIFNMRGPGMTMHRLPLFVWSVLVTAFLLLLSLPVLAGAITMLLTDRNFNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHIVSTFSGKPVFGYLGMVYAMISIGVLGFLVWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKIFSWIATMWGGSIQYKTPMLFAVGFIFLFTVGGLTGIVLANSGLDIALHDTYYVVAHFHYVLSMGAVFALFAGFYYWVGKIFGRTYPETLGQIHFWITFFGVNLTFFPMHFLGLSGMPRRIPDYPDAYAGWNALSSFGSYISVVGICCFFVIVTITLSSGKKKRCAPSPWAVEE

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue345

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU883303
EMBL· GenBank· DDBJ
ACJ66369.1
EMBL· GenBank· DDBJ
Genomic DNA
EU883304
EMBL· GenBank· DDBJ
ACJ66370.1
EMBL· GenBank· DDBJ
Genomic DNA
HM775207
EMBL· GenBank· DDBJ
ADN97109.1
EMBL· GenBank· DDBJ
Genomic DNA
KC211494
EMBL· GenBank· DDBJ
AGO86995.1
EMBL· GenBank· DDBJ
Genomic DNA
KC211495
EMBL· GenBank· DDBJ
AGO86996.1
EMBL· GenBank· DDBJ
Genomic DNA
KC211496
EMBL· GenBank· DDBJ
AGO86997.1
EMBL· GenBank· DDBJ
Genomic DNA
KC211498
EMBL· GenBank· DDBJ
AGO86999.1
EMBL· GenBank· DDBJ
Genomic DNA
KC211502
EMBL· GenBank· DDBJ
AGO87003.1
EMBL· GenBank· DDBJ
Genomic DNA
KC211503
EMBL· GenBank· DDBJ
AGO87004.1
EMBL· GenBank· DDBJ
Genomic DNA
KC211506
EMBL· GenBank· DDBJ
AGO87007.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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