C0HLT0 · IBBB4_HYAOR
- ProteinBowman-Birk type proteinase inhibitor B4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Serine protease inhibitor (PubMed:33666645).
Inhibits trypsin (Ki = 110 nM) and very weakly inhibits chymotrypsin (Ki =1200 nM) (PubMed:33666645).
Does not inhibit bacterial subtilisin (PubMed:33666645).
Inhibits trypsin (Ki = 110 nM) and very weakly inhibits chymotrypsin (Ki =1200 nM) (PubMed:33666645).
Does not inhibit bacterial subtilisin (PubMed:33666645).
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 14-15 | Reactive bond for trypsin | |||
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | serine-type endopeptidase inhibitor activity | |
Biological Process | negative regulation of endopeptidase activity |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameBowman-Birk type proteinase inhibitor B4
- Short namesHOSPI-B4
Organism names
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Asparagales > Hyacinthaceae > Hyacinthoideae > Hyacintheae > Hyacinthus
Accessions
- Primary accessionC0HLT0
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000452980 | 1-57 | Bowman-Birk type proteinase inhibitor B4 | ||
Disulfide bond | 6↔55 | ||||
Disulfide bond | 12↔17 | ||||
Disulfide bond | 26↔33 | ||||
Disulfide bond | 30↔47 | ||||
Keywords
- PTM
Expression
Tissue specificity
Expressed in bulb (at protein level).
Structure
Family & Domains
Sequence similarities
Belongs to the Bowman-Birk serine protease inhibitor family.