C0HLJ3 · CO1A1_NOTSH
- ProteinCollagen alpha-1(I) chain
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids998 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Type I collagen is a member of group I collagen (fibrillar forming collagen).
Miscellaneous
These protein fragments were extracted from ancient femur bone collected at Rampart Cave in Arizona.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | extracellular space | |
Molecular Function | extracellular matrix structural constituent conferring tensile strength | |
Biological Process | extracellular matrix organization |
Names & Taxonomy
Protein names
- Recommended nameCollagen alpha-1(I) chain
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Xenarthra > Pilosa > Folivora > Megatheriidae > Nothrotheriops
Accessions
- Primary accessionC0HLJ3
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000448470 | 1-998 | Collagen alpha-1(I) chain | ||
Modified residue | 25 | 4-hydroxyproline | |||
Modified residue | 28 | 4-hydroxyproline | |||
Modified residue | 30 | 4-hydroxyproline | |||
Modified residue | 39 | 4-hydroxyproline | |||
Modified residue | 42 | 4-hydroxyproline | |||
Modified residue | 45 | 4-hydroxyproline | |||
Modified residue | 59 | 4-hydroxyproline | |||
Modified residue | 74 | 4-hydroxyproline | |||
Modified residue | 80 | 4-hydroxyproline | |||
Modified residue | 89 | 4-hydroxyproline | |||
Modified residue | 95 | 4-hydroxyproline | |||
Modified residue | 98 | 5-hydroxylysine; alternate | |||
Glycosylation | 98 | O-linked (Gal...) hydroxylysine; alternate | |||
Modified residue | 104 | Phosphoserine | |||
Modified residue | 122 | 4-hydroxyproline | |||
Modified residue | 125 | 4-hydroxyproline | |||
Modified residue | 131 | 4-hydroxyproline | |||
Modified residue | 140 | 4-hydroxyproline | |||
Modified residue | 146 | 4-hydroxyproline | |||
Modified residue | 167 | 4-hydroxyproline | |||
Modified residue | 176 | 4-hydroxyproline | |||
Modified residue | 179 | 4-hydroxyproline | |||
Modified residue | 206 | 4-hydroxyproline | |||
Modified residue | 209 | 4-hydroxyproline | |||
Modified residue | 221 | 4-hydroxyproline | |||
Modified residue | 227 | 4-hydroxyproline | |||
Modified residue | 236 | 4-hydroxyproline | |||
Modified residue | 242 | 4-hydroxyproline | |||
Modified residue | 245 | 4-hydroxyproline | |||
Modified residue | 260 | 4-hydroxyproline | |||
Modified residue | 263 | 5-hydroxylysine | |||
Modified residue | 269 | 4-hydroxyproline | |||
Modified residue | 272 | 4-hydroxyproline | |||
Modified residue | 284 | 4-hydroxyproline | |||
Modified residue | 293 | 4-hydroxyproline | |||
Modified residue | 308 | 4-hydroxyproline | |||
Modified residue | 314 | 4-hydroxyproline | |||
Modified residue | 323 | 4-hydroxyproline | |||
Modified residue | 329 | 4-hydroxyproline | |||
Modified residue | 338 | 5-hydroxylysine | |||
Modified residue | 347 | 4-hydroxyproline | |||
Modified residue | 356 | 4-hydroxyproline | |||
Modified residue | 362 | 4-hydroxyproline | |||
Modified residue | 368 | 4-hydroxyproline | |||
Modified residue | 377 | 4-hydroxyproline | |||
Modified residue | 380 | 4-hydroxyproline | |||
Modified residue | 389 | 4-hydroxyproline | |||
Modified residue | 398 | 4-hydroxyproline | |||
Modified residue | 404 | 4-hydroxyproline | |||
Modified residue | 416 | 4-hydroxyproline | |||
Modified residue | 425 | 4-hydroxyproline | |||
Modified residue | 434 | 4-hydroxyproline | |||
Modified residue | 437 | 4-hydroxyproline | |||
Modified residue | 455 | 4-hydroxyproline | |||
Modified residue | 472 | 4-hydroxyproline | |||
Modified residue | 478 | 4-hydroxyproline | |||
Modified residue | 484 | 4-hydroxyproline | |||
Modified residue | 490 | 4-hydroxyproline | |||
Modified residue | 496 | 4-hydroxyproline | |||
Modified residue | 502 | 4-hydroxyproline | |||
Modified residue | 514 | 4-hydroxyproline | |||
Modified residue | 523 | 4-hydroxyproline | |||
Modified residue | 537 | 4-hydroxyproline | |||
Modified residue | 543 | 4-hydroxyproline | |||
Modified residue | 552 | 4-hydroxyproline | |||
Modified residue | 564 | 5-hydroxylysine | |||
Modified residue | 570 | 4-hydroxyproline | |||
Modified residue | 585 | 4-hydroxyproline | |||
Modified residue | 591 | 4-hydroxyproline | |||
Modified residue | 600 | Phosphoserine | |||
Modified residue | 612 | 4-hydroxyproline | |||
Modified residue | 618 | 4-hydroxyproline | |||
Modified residue | 621 | 4-hydroxyproline | |||
Modified residue | 630 | 4-hydroxyproline | |||
Modified residue | 636 | 4-hydroxyproline | |||
Modified residue | 654 | 4-hydroxyproline | |||
Modified residue | 663 | 4-hydroxyproline | |||
Modified residue | 672 | 4-hydroxyproline | |||
Modified residue | 675 | 5-hydroxylysine | |||
Modified residue | 684 | 4-hydroxyproline | |||
Modified residue | 690 | 4-hydroxyproline | |||
Modified residue | 698 | 3-hydroxyproline | |||
Modified residue | 699 | 4-hydroxyproline | |||
Modified residue | 708 | 4-hydroxyproline | |||
Modified residue | 711 | 4-hydroxyproline | |||
Modified residue | 732 | 4-hydroxyproline | |||
Modified residue | 741 | 4-hydroxyproline | |||
Modified residue | 749 | 4-hydroxyproline | |||
Modified residue | 758 | 4-hydroxyproline | |||
Modified residue | 776 | 4-hydroxyproline | |||
Modified residue | 785 | 4-hydroxyproline | |||
Modified residue | 788 | 4-hydroxyproline | |||
Modified residue | 794 | 4-hydroxyproline | |||
Modified residue | 809 | 4-hydroxyproline | |||
Modified residue | 815 | 4-hydroxyproline | |||
Modified residue | 821 | 4-hydroxyproline | |||
Modified residue | 830 | 4-hydroxyproline | |||
Modified residue | 836 | 4-hydroxyproline | |||
Modified residue | 845 | 5-hydroxylysine | |||
Modified residue | 856 | 4-hydroxyproline | |||
Modified residue | 859 | 4-hydroxyproline | |||
Modified residue | 862 | 4-hydroxyproline | |||
Modified residue | 907 | 5-hydroxylysine | |||
Modified residue | 919 | 5-hydroxylysine; alternate | |||
Glycosylation | 919 | O-linked (Gal...) hydroxylysine; alternate | |||
Modified residue | 934 | 4-hydroxyproline | |||
Modified residue | 937 | 4-hydroxyproline | |||
Modified residue | 955 | 4-hydroxyproline | |||
Modified residue | 970 | 4-hydroxyproline | |||
Modified residue | 975 | 3-hydroxyproline | |||
Modified residue | 976 | 4-hydroxyproline | |||
Modified residue | 990 | 3-hydroxyproline | |||
Modified residue | 991 | 4-hydroxyproline | |||
Modified residue | 993 | 3-hydroxyproline | |||
Modified residue | 994 | 4-hydroxyproline | |||
Modified residue | 996 | 3-hydroxyproline | |||
Modified residue | 997 | 4-hydroxyproline | |||
Post-translational modification
Contains mostly 4-hydroxyproline. Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline.
Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains.
O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide.
Keywords
- PTM
Expression
Tissue specificity
Expressed in bones.
Interaction
Subunit
Trimers of one alpha 2(I) and two alpha 1(I) chains.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-998 | Disordered | |||
Compositional bias | 18-59 | Pro residues | |||
Compositional bias | 252-266 | Pro residues | |||
Compositional bias | 382-405 | Pro residues | |||
Compositional bias | 655-669 | Pro residues | |||
Compositional bias | 701-715 | Pro residues | |||
Compositional bias | 733-747 | Pro residues | |||
Sequence similarities
Belongs to the fibrillar collagen family.
Family and domain databases
Sequence
- Sequence statusFragments
- Length998
- Mass (Da)89,146
- Last updated2019-11-13 v1
- Checksum64842BD4699508CB
Features
Showing features for non-terminal residue, non-adjacent residues, compositional bias, sequence uncertainty.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-adjacent residues | 7-8 | ||||
Compositional bias | 18-59 | Pro residues | |||
Sequence uncertainty | 24 | L or I | |||
Non-adjacent residues | 29-30 | ||||
Non-adjacent residues | 46-47 | ||||
Sequence uncertainty | 88 | L or I | |||
Sequence uncertainty | 94 | L or I | |||
Sequence uncertainty | 106 | L or I | |||
Sequence uncertainty | 139 | L or I | |||
Sequence uncertainty | 238 | I or L | |||
Compositional bias | 252-266 | Pro residues | |||
Sequence uncertainty | 289 | I or L | |||
Sequence uncertainty | 313 | L or I | |||
Sequence uncertainty | 367 | L or I | |||
Sequence uncertainty | 373 | L or I | |||
Compositional bias | 382-405 | Pro residues | |||
Non-adjacent residues | 471-472 | ||||
Sequence uncertainty | 477 | L or I | |||
Sequence uncertainty | 499 | L or I | |||
Non-adjacent residues | 530-531 | ||||
Non-adjacent residues | 532-533 | ||||
Sequence uncertainty | 539 | L or I | |||
Sequence uncertainty | 551 | L or I | |||
Sequence uncertainty | 578 | L or I | |||
Sequence uncertainty | 582 | I or L | |||
Compositional bias | 655-669 | Pro residues | |||
Sequence uncertainty | 666 | I or L | |||
Compositional bias | 701-715 | Pro residues | |||
Compositional bias | 733-747 | Pro residues | |||
Non-adjacent residues | 743-744 | ||||
Sequence uncertainty | 766 | I or L | |||
Sequence uncertainty | 775 | L or I | |||
Sequence uncertainty | 787 | L or I | |||
Sequence uncertainty | 817 | L or I | |||
Non-adjacent residues | 853-854 | ||||
Sequence uncertainty | 918 | I or L | |||
Sequence uncertainty | 927 | L or I | |||
Sequence uncertainty | 966 | L or I | |||
Sequence uncertainty | 969 | L or I | |||
Sequence uncertainty | 973 | I or L | |||
Non-terminal residue | 998 | ||||
Keywords
- Technical term