C0HLI6 · CO1A2_SCESX
- ProteinCollagen alpha-2(I) chain
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids413 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Type I collagen is a member of group I collagen (fibrillar forming collagen).
Miscellaneous
These protein fragments were extracted from an ancient phalanx bone collected at Arroyo Del Moro in Argentina.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region |
Names & Taxonomy
Protein names
- Recommended nameCollagen alpha-2(I) chain
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Xenarthra > Pilosa > Folivora > Mylodontidae > Scelidotherium
Accessions
- Primary accessionC0HLI6
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000448461 | 1-413 | Collagen alpha-2(I) chain | ||
Modified residue | 7 | 4-hydroxyproline | |||
Modified residue | 10 | 4-hydroxyproline | |||
Modified residue | 21 | 4-hydroxyproline | |||
Modified residue | 27 | 4-hydroxyproline | |||
Modified residue | 82 | 5-hydroxylysine; alternate | |||
Glycosylation | 82 | O-linked (Gal...) hydroxylysine; alternate | |||
Modified residue | 313 | 4-hydroxyproline | |||
Modified residue | 316 | 4-hydroxyproline | |||
Post-translational modification
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Keywords
- PTM
Expression
Tissue specificity
Expressed in bones.
Interaction
Subunit
Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts (via C-terminus) with TMEM131 (via PapD-L domain); the interaction is direct and is involved in assembly and TRAPPIII ER-to-Golgi transport complex-dependent secretion of collagen.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-413 | Disordered | |||
Compositional bias | 132-146 | Pro residues | |||
Sequence similarities
Belongs to the fibrillar collagen family.
Family and domain databases
Sequence
- Sequence statusFragments
- Length413
- Mass (Da)37,111
- Last updated2019-11-13 v1
- ChecksumBD8184C4CA899B13
Features
Showing features for non-terminal residue, sequence uncertainty, non-adjacent residues, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence uncertainty | 6 | L or I | |||
Non-adjacent residues | 12-13 | ||||
Sequence uncertainty | 14 | L or I | |||
Non-adjacent residues | 53-54 | ||||
Non-adjacent residues | 61-62 | ||||
Sequence uncertainty | 78 | L or I | |||
Non-adjacent residues | 82-83 | ||||
Sequence uncertainty | 102 | L or I | |||
Compositional bias | 132-146 | Pro residues | |||
Sequence uncertainty | 151 | L or I | |||
Non-adjacent residues | 159-160 | ||||
Sequence uncertainty | 170 | L or I | |||
Sequence uncertainty | 188 | L or I | |||
Sequence uncertainty | 197 | L or I | |||
Sequence uncertainty | 206 | L or I | |||
Non-adjacent residues | 210-211 | ||||
Sequence uncertainty | 216 | L or I | |||
Sequence uncertainty | 270 | L or I | |||
Sequence uncertainty | 279 | L or I | |||
Sequence uncertainty | 318 | L or I | |||
Sequence uncertainty | 324 | L or I | |||
Sequence uncertainty | 342 | L or I | |||
Non-adjacent residues | 378-379 | ||||
Sequence uncertainty | 386 | L or I | |||
Sequence uncertainty | 407 | L or I | |||
Non-terminal residue | 413 | ||||
Keywords
- Technical term