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C0HLA8 · MAMB5_DENJA

Function

function

Interacts with vasopressin V2 receptor (V2R/AVPR2), probably in a selective manner (PubMed:35122240).
Inhibits vasopressin binding human V2R in the nanomolar range (Ki=3.50 nM), and also potently inhibits vasopressin-induced cAMP production (IC50=21 nM). In vivo, intraperitoneal injection of this protein into rats increases diuresis by 6-fold, without any loss of electrolytes (PubMed:35122240).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionserine-type endopeptidase inhibitor activity
Molecular Functiontoxin activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Mambaquaretin-5
  • Short names
    MQ5
  • Alternative names
    • Upsilon-Dj2a

Organism names

Accessions

  • Primary accession
    C0HLA8

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

Type
IDPosition(s)Description
ChainPRO_00004575701-57Mambaquaretin-5
Disulfide bond5↔55
Disulfide bond14↔38
Disulfide bond30↔51

Keywords

Expression

Tissue specificity

Expressed by the venom gland.

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-55BPTI/Kunitz inhibitor

Domain

Exploits its two major loops and engages more positions in its interaction with V2R. The pharmacophore defined by numerous amino acids positioned in loop 1 (9 to 18) and loop 2 (34, 39 and 44) may be at the origin of the absolute selectivity of this protein for V2R.

Sequence similarities

Belongs to the venom Kunitz-type family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    57
  • Mass (Da)
    6,464
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    7C8A003C0486AD0C03197610580555CD
RPSFCNLPVKPGPCSGFFSAFYYSQKTNKCHSFTYSGCRGNGNRFRTIEECRRTCVG

Mass Spectrometry

Molecular mass is 6,453.95 Da. Determined by MALDI. Monoisotopic mass.

Keywords

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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