C0HKQ7 · CECA1_DROME
- ProteinCecropin-A1
- GeneCecA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria (PubMed:11266367, PubMed:2390977).
Functions in the imd/NF-kappa-B (Imd) epithelial and humoral immune response to Gram-negative bacteria (PubMed:11266367).
Functions in the imd/NF-kappa-B (Imd) epithelial and humoral immune response to Gram-negative bacteria (PubMed:11266367).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Biological Process | antibacterial humoral response | |
Biological Process | defense response to Gram-negative bacterium | |
Biological Process | defense response to Gram-positive bacterium | |
Biological Process | defense response to insect | |
Biological Process | defense response to virus | |
Biological Process | humoral immune response | |
Biological Process | innate immune response | |
Biological Process | response to bacterium | |
Biological Process | response to Gram-negative bacterium |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCecropin-A1
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionC0HKQ7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 8 | in strain: M26 | ||||
Sequence: V → A | ||||||
Natural variant | 11 | in strain: B226 and B316 | ||||
Sequence: A → P | ||||||
Natural variant | 14 | in strain: MJ3 | ||||
Sequence: L → V | ||||||
Natural variant | 20 | in strain: B316 | ||||
Sequence: Q → E | ||||||
Natural variant | 45 | in strain: M40 | ||||
Sequence: I → IFT | ||||||
Natural variant | 45 | in strain: MJ1 | ||||
Sequence: I → V | ||||||
Natural variant | 56 | in strain: MJ1 | ||||
Sequence: N → D | ||||||
Natural variant | 61 | in strain: Z24 | ||||
Sequence: A → G |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 8 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MNFYNIFVFVALILAITIGQSEA | ||||||
Chain | PRO_0000441212 | 24-62 | Cecropin-A1 | |||
Sequence: GWLKKIGKKIERVGQHTRDATIQGLGIAQQAANVAATAR | ||||||
Modified residue | 62 | Arginine amide | ||||
Sequence: R |
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Hemolymph (at protein level) (PubMed:16510152).
Strongly expressed in larval, pupal and adult fat body and hemocytes after injection of bacteria (PubMed:2390977).
Maximal expression in the adult involves fat body cells of the head, thorax and abdomen (PubMed:2390977).
Strongly expressed in larval, pupal and adult fat body and hemocytes after injection of bacteria (PubMed:2390977).
Maximal expression in the adult involves fat body cells of the head, thorax and abdomen (PubMed:2390977).
Induction
By bacterial infection (at protein level) (PubMed:16510152).
Induced as part of the humoral response to a bacterial invasion (PubMed:2390977).
Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours (PubMed:2104802).
Similar response is seen when flies ingest bacteria present in their food (PubMed:2104802).
8 hours after bacterial infection of embryos (2-6 hours after hatching), up-regulated in the larval epidermis and 16 hour post-infection is up-regulated in the larval fat body (PubMed:11266367).
Up-regulated in the larval fat body by injection of bacterial lipopolysaccharides (LPS), but not up-regulated in the epidermis (PubMed:11266367).
Induced as part of the humoral response to a bacterial invasion (PubMed:2390977).
Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours (PubMed:2104802).
Similar response is seen when flies ingest bacteria present in their food (PubMed:2104802).
8 hours after bacterial infection of embryos (2-6 hours after hatching), up-regulated in the larval epidermis and 16 hour post-infection is up-regulated in the larval fat body (PubMed:11266367).
Up-regulated in the larval fat body by injection of bacterial lipopolysaccharides (LPS), but not up-regulated in the epidermis (PubMed:11266367).
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the cecropin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length63
- Mass (Da)6,771
- Last updated2017-08-30 v1
- ChecksumF709070C5BEC7D74
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X16972 EMBL· GenBank· DDBJ | CAA34843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF018964 EMBL· GenBank· DDBJ | AAB82461.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF018965 EMBL· GenBank· DDBJ | AAB82462.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF018966 EMBL· GenBank· DDBJ | AAB82463.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF018967 EMBL· GenBank· DDBJ | AAB82464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF018968 EMBL· GenBank· DDBJ | AAB82465.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF018969 EMBL· GenBank· DDBJ | AAB82466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF018970 EMBL· GenBank· DDBJ | AAB82467.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF018971 EMBL· GenBank· DDBJ | AAB82468.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF018972 EMBL· GenBank· DDBJ | AAB82469.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF018973 EMBL· GenBank· DDBJ | AAB82470.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF018974 EMBL· GenBank· DDBJ | AAB82471.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB010791 EMBL· GenBank· DDBJ | BAA28719.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB010792 EMBL· GenBank· DDBJ | BAA28723.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB010793 EMBL· GenBank· DDBJ | BAA28727.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB010794 EMBL· GenBank· DDBJ | BAA28730.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB010796 EMBL· GenBank· DDBJ | BAA28736.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB010797 EMBL· GenBank· DDBJ | BAA28740.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y16852 EMBL· GenBank· DDBJ | CAA76425.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y16853 EMBL· GenBank· DDBJ | CAA76431.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y16854 EMBL· GenBank· DDBJ | CAA76437.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y16854 EMBL· GenBank· DDBJ | CAA76439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y16855 EMBL· GenBank· DDBJ | CAA76443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y16856 EMBL· GenBank· DDBJ | CAA76449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y16856 EMBL· GenBank· DDBJ | CAA76451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y16857 EMBL· GenBank· DDBJ | CAA76455.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y16858 EMBL· GenBank· DDBJ | CAA76461.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y16859 EMBL· GenBank· DDBJ | CAA76467.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y16861 EMBL· GenBank· DDBJ | CAA76477.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAF57025.1 EMBL· GenBank· DDBJ | Genomic DNA |