C0HJN6 · CO1A2_HIPAM
- ProteinCollagen alpha-2(I) chain
- GeneCOL1A2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids887 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Type I collagen is a member of group I collagen (fibrillar forming collagen).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | collagen trimer | |
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | extracellular space | |
Molecular Function | extracellular matrix structural constituent conferring tensile strength | |
Biological Process | extracellular matrix organization |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCollagen alpha-2(I) chain
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Ancodonta > Hippopotamidae > Hippopotamus
Accessions
- Primary accessionC0HJN6
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000433502 | 1-887 | Collagen alpha-2(I) chain | ||
Post-translational modification
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Keywords
- PTM
Expression
Tissue specificity
Forms the fibrils of tendon, ligaments and bones. In bones, the fibrils are mineralized with calcium hydroxyapatite.
Interaction
Subunit
Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts (via C-terminus) with TMEM131 (via PapD-L domain); the interaction is direct and is involved in assembly and TRAPPIII ER-to-Golgi transport complex-dependent secretion of collagen.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-887 | Disordered | |||
Compositional bias | 149-163 | Pro residues | |||
Compositional bias | 610-624 | Pro residues | |||
Compositional bias | 871-887 | Pro residues | |||
Sequence similarities
Belongs to the fibrillar collagen family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragments
- Length887
- Mass (Da)79,760
- Last updated2015-07-22 v1
- Checksum647120E002F4FDC7
Features
Showing features for sequence uncertainty, non-adjacent residues, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence uncertainty | 5 | I or L | |||
Sequence uncertainty | 83 | I or L | |||
Sequence uncertainty | 89 | I or L | |||
Sequence uncertainty | 95 | I or L | |||
Sequence uncertainty | 98 | I or L | |||
Non-adjacent residues | 114-115 | ||||
Sequence uncertainty | 119 | I or L | |||
Compositional bias | 149-163 | Pro residues | |||
Sequence uncertainty | 150 | I or L | |||
Sequence uncertainty | 168 | I or L | |||
Sequence uncertainty | 188 | I or L | |||
Non-adjacent residues | 200-201 | ||||
Sequence uncertainty | 205 | I or L | |||
Sequence uncertainty | 214 | I or L | |||
Sequence uncertainty | 220 | I or L | |||
Sequence uncertainty | 235 | I or L | |||
Non-adjacent residues | 245-246 | ||||
Sequence uncertainty | 251 | I or L | |||
Sequence uncertainty | 267 | I or L | |||
Sequence uncertainty | 278 | I or L | |||
Sequence uncertainty | 287 | I or L | |||
Sequence uncertainty | 299 | I or L | |||
Non-adjacent residues | 312-313 | ||||
Sequence uncertainty | 321 | I or L | |||
Sequence uncertainty | 332 | I or L | |||
Sequence uncertainty | 335 | I or L | |||
Non-adjacent residues | 348-349 | ||||
Sequence uncertainty | 350 | I or L | |||
Non-adjacent residues | 361-362 | ||||
Sequence uncertainty | 370 | I or L | |||
Non-adjacent residues | 389-390 | ||||
Sequence uncertainty | 407 | I or L | |||
Sequence uncertainty | 425 | I or L | |||
Sequence uncertainty | 431 | I or L | |||
Sequence uncertainty | 456 | I or L | |||
Sequence uncertainty | 491 | I or L | |||
Sequence uncertainty | 500 | I or L | |||
Sequence uncertainty | 512 | I or L | |||
Non-adjacent residues | 513-514 | ||||
Non-adjacent residues | 586-587 | ||||
Compositional bias | 610-624 | Pro residues | |||
Sequence uncertainty | 613 | I or L | |||
Sequence uncertainty | 628 | I or L | |||
Non-adjacent residues | 656-657 | ||||
Sequence uncertainty | 663 | I or L | |||
Sequence uncertainty | 664 | I or L | |||
Sequence uncertainty | 670 | I or L | |||
Sequence uncertainty | 672 | I or L | |||
Sequence uncertainty | 681 | I or L | |||
Sequence uncertainty | 694 | I or L | |||
Sequence uncertainty | 696 | I or L | |||
Non-adjacent residues | 735-736 | ||||
Non-adjacent residues | 745-746 | ||||
Sequence uncertainty | 790 | I or L | |||
Sequence uncertainty | 805 | I or L | |||
Sequence uncertainty | 808 | I or L | |||
Sequence uncertainty | 814 | I or L | |||
Sequence uncertainty | 817 | I or L | |||
Sequence uncertainty | 820 | I or L | |||
Sequence uncertainty | 865 | I or L | |||
Non-adjacent residues | 866-867 | ||||
Compositional bias | 871-887 | Pro residues | |||
Keywords
- Technical term