C0HJN6 · CO1A2_HIPAM

Function

function

Type I collagen is a member of group I collagen (fibrillar forming collagen).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcollagen trimer
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentextracellular space
Molecular Functionextracellular matrix structural constituent conferring tensile strength
Biological Processextracellular matrix organization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Collagen alpha-2(I) chain
  • Alternative names
    • Alpha-2 type I collagen

Gene names

    • Name
      COL1A2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Ancodonta > Hippopotamidae > Hippopotamus

Accessions

  • Primary accession
    C0HJN6

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004335021-887Collagen alpha-2(I) chain

Post-translational modification

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords

Expression

Tissue specificity

Forms the fibrils of tendon, ligaments and bones. In bones, the fibrils are mineralized with calcium hydroxyapatite.

Interaction

Subunit

Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts (via C-terminus) with TMEM131 (via PapD-L domain); the interaction is direct and is involved in assembly and TRAPPIII ER-to-Golgi transport complex-dependent secretion of collagen.

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-887Disordered
Compositional bias149-163Pro residues
Compositional bias610-624Pro residues
Compositional bias871-887Pro residues

Sequence similarities

Belongs to the fibrillar collagen family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragments
  • Length
    887
  • Mass (Da)
    79,760
  • Last updated
    2015-07-22 v1
  • Checksum
    647120E002F4FDC7
GPMGIMGPRGPPGASGAPGPQGFQGPPGEPGEPGQTGPAGARGPPGPPGKAGEDGHPGKPGRSGERGVVGPQGARGFPGTPGIPGFKGIRGHNGIDGIKGQPGAPGVKGEPGAPGARGIPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGPVGSPGASGPAGPRGEVGIPGVSGPVGPPGNGAAGIPGVAGAPGIPGPRGIPGPVGAAGATGARGIVGEPGPAGSKAGPQGIPGPSGEEGKRGSTGEIGPAGPPGPPGIRGSPGSRGIPGADGRAGVMGIPGSRGATGPAGVRGFPGSPGNIGPAGKEGPVGIPGIDGRPGPTGPAGARNIGFPGPKGPTGDNGDKGHAGIAGARGAPGPDGNNGAQGPPQGGKGEQGPAGPPGFQGIPGPAGTAGEAGKPGERGIPGEFGIPGPAGPRGERGPPGESGAAGPTGPIGNRGPSGPAGPDGNKGEPGVVGAPGTAGPSGPSGIPGERGAAGIPGPKGEKGEPGIRRDGARGAPGAVGAPGPAGANGDRGEAGPAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGTRGDGGPPGATGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGIRGPRGDQGPVGRSGETGASGPPGFAGEKTPGPQGIIGAPGFIGIPGSRGERGIPGVAGSVGEPGPIGIAGPPGARGPPGAVGNPGVNGAPGEAGRDGNPGSDGPPGRGHKGERGYPGAGAPGPQGPVGPTGKHGNRGEPGPAGVVGPTGAVGPRGPSGPQGIRGDKGEPGDKGPRGIPGIKGHNGIQGIPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPVGKDGRTGHPGAVGPAGIRGSQGPAGPPGPPGPPGPPGPS

Features

Showing features for sequence uncertainty, non-adjacent residues, compositional bias.

Type
IDPosition(s)Description
Sequence uncertainty5I or L
Sequence uncertainty83I or L
Sequence uncertainty89I or L
Sequence uncertainty95I or L
Sequence uncertainty98I or L
Non-adjacent residues114-115
Sequence uncertainty119I or L
Compositional bias149-163Pro residues
Sequence uncertainty150I or L
Sequence uncertainty168I or L
Sequence uncertainty188I or L
Non-adjacent residues200-201
Sequence uncertainty205I or L
Sequence uncertainty214I or L
Sequence uncertainty220I or L
Sequence uncertainty235I or L
Non-adjacent residues245-246
Sequence uncertainty251I or L
Sequence uncertainty267I or L
Sequence uncertainty278I or L
Sequence uncertainty287I or L
Sequence uncertainty299I or L
Non-adjacent residues312-313
Sequence uncertainty321I or L
Sequence uncertainty332I or L
Sequence uncertainty335I or L
Non-adjacent residues348-349
Sequence uncertainty350I or L
Non-adjacent residues361-362
Sequence uncertainty370I or L
Non-adjacent residues389-390
Sequence uncertainty407I or L
Sequence uncertainty425I or L
Sequence uncertainty431I or L
Sequence uncertainty456I or L
Sequence uncertainty491I or L
Sequence uncertainty500I or L
Sequence uncertainty512I or L
Non-adjacent residues513-514
Non-adjacent residues586-587
Compositional bias610-624Pro residues
Sequence uncertainty613I or L
Sequence uncertainty628I or L
Non-adjacent residues656-657
Sequence uncertainty663I or L
Sequence uncertainty664I or L
Sequence uncertainty670I or L
Sequence uncertainty672I or L
Sequence uncertainty681I or L
Sequence uncertainty694I or L
Sequence uncertainty696I or L
Non-adjacent residues735-736
Non-adjacent residues745-746
Sequence uncertainty790I or L
Sequence uncertainty805I or L
Sequence uncertainty808I or L
Sequence uncertainty814I or L
Sequence uncertainty817I or L
Sequence uncertainty820I or L
Sequence uncertainty865I or L
Non-adjacent residues866-867
Compositional bias871-887Pro residues

Keywords

Similar Proteins

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