C0HJD2 · ALBU_DAMDA
- ProteinSerum albumin
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs (By similarity).
Its main function is the regulation of the colloidal osmotic pressure of blood (By similarity).
Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity).
Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity).
Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity).
The shared binding site between zinc and calcium suggests a crosstalk between zinc and calcium transport in the blood (By similarity).
The rank order of affinity is zinc > calcium > magnesium (By similarity).
Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity).
Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
Its main function is the regulation of the colloidal osmotic pressure of blood (By similarity).
Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity).
Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity).
Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity).
The shared binding site between zinc and calcium suggests a crosstalk between zinc and calcium transport in the blood (By similarity).
The rank order of affinity is zinc > calcium > magnesium (By similarity).
Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity).
Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | lipid binding | |
Molecular Function | metal ion binding |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSerum albumin
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Cervidae > Cervinae > Dama
Accessions
- Primary accessionC0HJD2
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000423369 | 1-10 | Serum albumin | |||
Sequence: DTHKSEIAHR | ||||||
Modified residue | 5 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Expression
Tissue specificity
Expressed in placenta, specifically the maternal caruncula tissue (MCT) (at protein level).
Interaction
Subunit
Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity).
Interacts with TASOR (By similarity).
In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB
Interacts with TASOR (By similarity).
In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB