C0FRH3 · C0FRH3_9FIRM

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site17-22substrate
Active site80Proton acceptor
Binding site80Mg2+ (UniProtKB | ChEBI)
Binding site81substrate
Binding site163-166substrate
Binding site186substrate
Binding site191-192substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      ROSEINA2194_01334

Organism names

Accessions

  • Primary accession
    C0FRH3

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    208
  • Mass (Da)
    23,120
  • Last updated
    2009-05-05 v1
  • Checksum
    6773CD5AFF6EDB12
MHLRKDIKKMTKIIFATGNAGKMREIRDIMADLDVELLSMKEAGIKLDIVEDGKTFEENALIKARAVSKEAPGAIVMADDSGLEVDYLHKKPGIYSARFIGEDISYDIKNQAILDLLAGVPKEKRTARFVCSIAAVLPDGREFVTRETMEGYIGDKIAGENGFGYDPIFCVEKYGCTTAELSEEQKNEISHRGKALRAMKEKLAKENL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACFY01000054
EMBL· GenBank· DDBJ
EEG94826.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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