C0DZY8 · C0DZY8_9CORY
- ProteinUroporphyrinogen decarboxylase
- GenehemE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids330 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Catalytic activity
- 4 H+ + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 2-6 | substrate | ||||
Sequence: RQAGR | ||||||
Binding site | 51 | substrate | ||||
Sequence: D | ||||||
Site | 51 | Transition state stabilizer | ||||
Sequence: D | ||||||
Binding site | 126 | substrate | ||||
Sequence: Y | ||||||
Binding site | 181 | substrate | ||||
Sequence: S | ||||||
Binding site | 304 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | uroporphyrinogen decarboxylase activity | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUroporphyrinogen decarboxylase
- EC number
- Short namesUPD ; URO-D
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Corynebacteriaceae > Corynebacterium
Accessions
- Primary accessionC0DZY8
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 114-130 | Uroporphyrinogen decarboxylase (URO-D) | ||||
Sequence: IGFAGAPFTLASYLVEG |
Sequence similarities
Belongs to the uroporphyrinogen decarboxylase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length330
- Mass (Da)35,464
- Last updated2009-05-05 v1
- Checksum08E483FE712DBC7C