B9VPZ5 · B9VPZ5_BOVIN
- ProteinLactotransferrin
- GeneLF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids708 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site.
The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites.
Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 92 | ||||
Active site | 278 | Nucleophile | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | iron ion binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | antibacterial humoral response | |
Biological Process | antifungal humoral response | |
Biological Process | ossification | |
Biological Process | proteolysis | |
Biological Process | regulation of cytokine production |
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLactotransferrin
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionB9VPZ5
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Protein family/group databases
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-19 | ||||
Chain | PRO_5009949412 | 20-708 | Lactotransferrin | ||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 25-352 | Transferrin-like | |||
Domain | 364-693 | Transferrin-like | |||
Sequence similarities
Belongs to the transferrin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length708
- Mass (Da)78,056
- Last updated2009-03-24 v1
- MD5 Checksum5BD2F1AB233029725BC96E2F289FFE25
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ589071 EMBL· GenBank· DDBJ | ACM24792.1 EMBL· GenBank· DDBJ | mRNA |