B9U5M9 · B9U5M9_DICCH
- ProteinLactoylglutathione lyase
- GenegloA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids135 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
Catalytic activity
- (R)-S-lactoylglutathione = methylglyoxal + glutathione
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 nickel ion per subunit.
Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
Pathway
Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 56 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 74 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Active site | 122 | Proton donor/acceptor | |||
Binding site | 122 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | lactoylglutathione lyase activity | |
Molecular Function | metal ion binding | |
Biological Process | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLactoylglutathione lyase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Pectobacteriaceae > Dickeya
Accessions
- Primary accessionB9U5M9
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Sequence
- Sequence statusComplete
- Length135
- Mass (Da)14,737
- Last updated2009-03-24 v1
- MD5 Checksum7F283FEEC54788ABB9DF5BB9AFEAD36D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU443200 EMBL· GenBank· DDBJ | ACC62399.1 EMBL· GenBank· DDBJ | Genomic DNA |