B9TWY1 · B9TWY1_CHELB

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • Cl
    • Ex06A11
    • Ex06A12
    • Ex06B1
    • Ex06B10
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Mugilomorphae > Mugilidae > Chelon

Accessions

  • Primary accession
    B9TWY1

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical
Transmembrane36-58Helical
Transmembrane92-112Helical
Transmembrane132-154Helical
Transmembrane166-193Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-217Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    217
  • Mass (Da)
    23,105
  • Last updated
    2009-03-24 v1
  • Checksum
    9412BAF8C898A9D6
LYLVFGAWAGMVGTALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLASNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAISQYQTPLFVWAVLITAVLLLLSLPVLAAGITMLLTDRNLNTSFFDPAGGGDPILYQHL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue217

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU392233
EMBL· GenBank· DDBJ
ACC96204.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ552826
EMBL· GenBank· DDBJ
AHW77577.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ552858
EMBL· GenBank· DDBJ
AHW77609.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ552871
EMBL· GenBank· DDBJ
AHW77622.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ552931
EMBL· GenBank· DDBJ
AHW77682.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ553053
EMBL· GenBank· DDBJ
AHW77804.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ553132
EMBL· GenBank· DDBJ
AHW77883.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ553145
EMBL· GenBank· DDBJ
AHW77896.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ553183
EMBL· GenBank· DDBJ
AHW77934.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ553192
EMBL· GenBank· DDBJ
AHW77943.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ553284
EMBL· GenBank· DDBJ
AHW78035.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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