B9TQX1 · UCMA_ACINA
- ProteinUnique cartilage matrix-associated protein
- Geneucma
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids139 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular matrix | |
Cellular Component | extracellular region | |
Biological Process | embryonic skeletal system development | |
Biological Process | regulation of osteoblast differentiation |
Names & Taxonomy
Protein names
- Recommended nameUnique cartilage matrix-associated protein
- Cleaved into 1 chains
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Chondrostei > Acipenseriformes > Acipenseridae > Acipenser
Accessions
- Primary accessionB9TQX1
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, propeptide, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MNWNQIIFISLIATVLILAIANEAES | ||||||
Propeptide | PRO_0000371235 | 27-65 | Ucma-N | |||
Sequence: AAVRTDKSDIKREDGENMKKRIFMQESEATAFLKRRGRR | ||||||
Chain | PRO_0000371234 | 27-139 | Unique cartilage matrix-associated protein | |||
Sequence: AAVRTDKSDIKREDGENMKKRIFMQESEATAFLKRRGRRSTKSKDEVNAENRQRLAADERRREYYEEQRNEFENYVEEERDEQQERNREKTEQWREYHYDGLYPSYQYNRHHI | ||||||
Chain | PRO_0000371236 | 66-139 | Unique cartilage matrix-associated protein C-terminal fragment | |||
Sequence: STKSKDEVNAENRQRLAADERRREYYEEQRNEFENYVEEERDEQQERNREKTEQWREYHYDGLYPSYQYNRHHI | ||||||
Modified residue | 72 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 76 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 85 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 89 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 92 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 93 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 97 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 99 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 103 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 104 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 105 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 108 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 111 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 115 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 118 | 4-carboxyglutamate | ||||
Sequence: E | ||||||
Modified residue | 122 | 4-carboxyglutamate | ||||
Sequence: E |
Post-translational modification
Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation.
Sulfated on tyrosine residues.
Keywords
- PTM
Expression
Tissue specificity
Detected in all tissues tested: heart, liver, kidney, muscle, gonads, brain, ganoid plate, anterior kidney, spleen, spine, cleithrum, head plate, operculum, skull, mandibula, branchial arches, anterior vertebra, and posterior vertebra. Expression is highest in the cartilaginous tissues (skull, mandibula, branchial arches, anterior vertebra and posterior vertebra), with the highest levels found in posterior vertebra. Found in mature and immature chondrocytes within the vertebra and mandibula, and in the chordoblast layer of the notochord in vertebra.
Structure
Family & Domains
Features
Showing features for region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 60-117 | Disordered | ||||
Sequence: KRRGRRSTKSKDEVNAENRQRLAADERRREYYEEQRNEFENYVEEERDEQQERNREKT | ||||||
Coiled coil | 70-123 | |||||
Sequence: KDEVNAENRQRLAADERRREYYEEQRNEFENYVEEERDEQQERNREKTEQWREY |
Sequence similarities
Belongs to the UCMA family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length139
- Mass (Da)16,998
- Last updated2009-03-24 v1
- Checksum43D214F731EECB93
Keywords
- Technical term