B9KAQ6 · UPP_THENN

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site795-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1045-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site131-1395-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site194uracil (UniProtKB | ChEBI)
Binding site199-201uracil (UniProtKB | ChEBI)
Binding site2005-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • Ordered locus names
      CTN_1863

Organism names

Accessions

  • Primary accession
    B9KAQ6

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001648381-209Uracil phosphoribosyltransferase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    209
  • Mass (Da)
    23,184
  • Last updated
    2009-03-24 v1
  • Checksum
    FC9B9DE74A7975E8
MKNLVVVDHPLIKHKLTIMRDKNTGPKEFRELLKEITLLLAYEATRHLKCEEVEVETPITKTTGYRINDKDIVVVPILRAGLVMADGILELLPNASVGHIGIYRDPETLRAVEYYAKLPPLDGDKEVFLLDPMLATGVSSVKALDILKENGARKITLVALIAAPEGVEAVEEKHSDVKIYVAALDERLNDHGYIIPGLGDAGDRLFRTK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000916
EMBL· GenBank· DDBJ
ACM24039.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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