B9J7B2 · HEM6_RHIR8
- ProteinOxygen-dependent coproporphyrinogen-III oxidase
- GenehemF
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids303 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
Catalytic activity
- coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen IX + 2 CO2 + 2 H2O
Cofactor
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 117 | substrate | |||
Binding site | 121 | a divalent metal cation (UniProtKB | ChEBI) | |||
Active site | 131 | Proton donor | |||
Binding site | 131 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 133-135 | substrate | |||
Binding site | 169 | a divalent metal cation (UniProtKB | ChEBI) | |||
Binding site | 199 | a divalent metal cation (UniProtKB | ChEBI) | |||
Site | 199 | Important for dimerization | |||
Binding site | 286-288 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | coproporphyrinogen oxidase activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein homodimerization activity | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOxygen-dependent coproporphyrinogen-III oxidase
- EC number
- Short namesCPO ; Coprogen oxidase ; Coproporphyrinogenase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Rhizobium/Agrobacterium group > Rhizobium
Accessions
- Primary accessionB9J7B2
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000133173 | 1-303 | Oxygen-dependent coproporphyrinogen-III oxidase | ||
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 268-303 | Important for dimerization | |||
Sequence similarities
Belongs to the aerobic coproporphyrinogen-III oxidase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length303
- Mass (Da)34,861
- Last updated2009-03-24 v1
- Checksum7E5120E0F91EEF45
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000628 EMBL· GenBank· DDBJ | ACM27219.1 EMBL· GenBank· DDBJ | Genomic DNA |