B9EBV8 · B9EBV8_MACCJ
- ProteinDNA topoisomerase 4 subunit A
- GenegrlA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids803 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 39 | Interaction with DNA | ||||
Sequence: K | ||||||
Site | 75 | Interaction with DNA | ||||
Sequence: H | ||||||
Site | 77 | Interaction with DNA | ||||
Sequence: H | ||||||
Site | 88 | Interaction with DNA | ||||
Sequence: R | ||||||
Site | 94 | Interaction with DNA | ||||
Sequence: K | ||||||
Site | 118 | Transition state stabilizer | ||||
Sequence: R | ||||||
Active site | 119 | O-(5'-phospho-DNA)-tyrosine intermediate | ||||
Sequence: Y |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex | |
Cellular Component | extrinsic component of plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Biological Process | chromosome segregation | |
Biological Process | DNA topological change |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 4 subunit A
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Macrococcoides
Accessions
- Primary accessionB9EBV8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-461 | DNA topoisomerase type IIA | ||||
Sequence: LPLEDVIGDRFGRYSKYIIQDRAIPDVRDGLKPVQRRILFAMYAEGNTYDKNYRKSAKTVGNVIGNYHPHGDTSVYDAMVRMSQDWKLRHVLVEMHGNNGSIDNDPPAAMRYTEAKLSKLANILLEDINKETVDFVQNFDDTAMEPMVLPANYPNLLVNGSTGISAGYATDIPPHNLDEVINATLKVIDKPNISTDEIMKVLPGPDFPTGGIIMGKSGIKQAYETGRGKIQVRGKVDIEKLRGGREEIIISEIPFEVNKSNLVKRIDELRADKKVDGIIEVRDETDRNGLRIAIELKKDANSEGILNFLYKNTDLQIAYNFNMVAISDRRPKLLGVRDMLNSFISHQKEVVTRRSQYDYDHAEKRMHIVEGLMKALSILDQVIKVIRNSSNKADAKHNLIHKFNFTEAQAEAIVMLQLYRLTNTDIVALEAEHEALKDRLKQLSLILNDETHLK | ||||||
Coiled coil | 426-493 | |||||
Sequence: YRLTNTDIVALEAEHEALKDRLKQLSLILNDETHLKKVIKKELKAIQKEFKEERLSQIEEKIAEIKIS |
Sequence similarities
Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length803
- Mass (Da)91,191
- Last updated2009-03-24 v1
- ChecksumBF2D27C788854502
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP009484 EMBL· GenBank· DDBJ | BAH17719.1 EMBL· GenBank· DDBJ | Genomic DNA |