B9EBV8 · B9EBV8_MACCJ

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Features

Showing features for site, active site.

1803100200300400500600700800
TypeIDPosition(s)Description
Site39Interaction with DNA
Site75Interaction with DNA
Site77Interaction with DNA
Site88Interaction with DNA
Site94Interaction with DNA
Site118Transition state stabilizer
Active site119O-(5'-phospho-DNA)-tyrosine intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Cellular ComponentDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
Cellular Componentextrinsic component of plasma membrane
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit A
  • EC number
  • Alternative names
    • Topoisomerase IV subunit A

Gene names

    • Name
      grlA
    • Synonyms
      parC
    • Ordered locus names
      MCCL_1012

Organism names

Accessions

  • Primary accession
    B9EBV8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, coiled coil.

TypeIDPosition(s)Description
Domain8-461DNA topoisomerase type IIA
Coiled coil426-493

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    803
  • Mass (Da)
    91,191
  • Last updated
    2009-03-24 v1
  • Checksum
    BF2D27C788854502
MNENIQSLPLEDVIGDRFGRYSKYIIQDRAIPDVRDGLKPVQRRILFAMYAEGNTYDKNYRKSAKTVGNVIGNYHPHGDTSVYDAMVRMSQDWKLRHVLVEMHGNNGSIDNDPPAAMRYTEAKLSKLANILLEDINKETVDFVQNFDDTAMEPMVLPANYPNLLVNGSTGISAGYATDIPPHNLDEVINATLKVIDKPNISTDEIMKVLPGPDFPTGGIIMGKSGIKQAYETGRGKIQVRGKVDIEKLRGGREEIIISEIPFEVNKSNLVKRIDELRADKKVDGIIEVRDETDRNGLRIAIELKKDANSEGILNFLYKNTDLQIAYNFNMVAISDRRPKLLGVRDMLNSFISHQKEVVTRRSQYDYDHAEKRMHIVEGLMKALSILDQVIKVIRNSSNKADAKHNLIHKFNFTEAQAEAIVMLQLYRLTNTDIVALEAEHEALKDRLKQLSLILNDETHLKKVIKKELKAIQKEFKEERLSQIEEKIAEIKISKEILVPNEETVISITREGYIKRTSPRSFNASGVTDIGMKEDDQLLAYHESNLQHITLVFTDKGRYMYIPNHQLPEIRWKDLGTHISQIVPIDSDERVIHMITVTDFNSEVKILAATRNGMIKLSSLKDFEVTRYSRPLINMKLKGNDVVNTIHVVTGSEHILVVTKQGMSLHYSLTELNDTGLKAAGVKSINLKDDDVVITTEIIYPESSLLIATQRGAMKKMDIQLFEEAKRAQRGLMILKELKSNPHHIIGAYIITEDMAYTLVSEHHEKHGKTKAIRKTDRYTNGSFIIDEKDFGKVVKLYINSVDL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP009484
EMBL· GenBank· DDBJ
BAH17719.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp