B9DGI8 · BZP63_ARATH
- ProteinBasic leucine zipper 63
- GeneBZIP63
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids314 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor involved in controlling responses to starvation (PubMed:26263501).
BZIP2-BZIP63-KIN10 complex binds to the ETFQO promoter to up-regulate its transcription (PubMed:29348240).
BZIP2-BZIP63-KIN10 complex binds to the ETFQO promoter to up-regulate its transcription (PubMed:29348240).
Activity regulation
Up-regulated by KIN10 under a phosphorylation-dependent manner.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | identical protein binding | |
Molecular Function | kinase binding | |
Molecular Function | protein heterodimerization activity | |
Biological Process | cellular response to abscisic acid stimulus | |
Biological Process | cellular response to glucose stimulus | |
Biological Process | cellular response to starvation | |
Biological Process | entrainment of circadian clock |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameBasic leucine zipper 63
- Short namesAtbZIP63; bZIP protein 63
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionB9DGI8
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Starvation-related phenotype with reduced growth and accumulation of anthocyanins.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 29 | Reduces its activity. Abolishes the formation of the BZIP2-BZIP63 heterodimer; when associated with A-294 and A-300. | ||||
Sequence: S → A | ||||||
Mutagenesis | 160 | Normal DNA-binding. | ||||
Sequence: S → A | ||||||
Mutagenesis | 160 | Reduced DNA-binding to C-box motif. | ||||
Sequence: S → D | ||||||
Mutagenesis | 164 | Normal DNA-binding. | ||||
Sequence: S → A | ||||||
Mutagenesis | 164 | Impaired DNA-binding to C-box motif. | ||||
Sequence: S → D | ||||||
Mutagenesis | 168 | Normal DNA-binding. | ||||
Sequence: S → A | ||||||
Mutagenesis | 168 | Impaired DNA-binding to C-box motif. | ||||
Sequence: S → D | ||||||
Mutagenesis | 294 | Reduces activity. Abolishes the formation of the BZIP2-BZIP63 heterodimer; when associated with A-29 and A-300. | ||||
Sequence: S → A | ||||||
Mutagenesis | 300 | Reduces activity. Abolishes the formation of the BZIP2-BZIP63 heterodimer; when associated with A-29 and A-294. | ||||
Sequence: S → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 34 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000416560 | 1-314 | Basic leucine zipper 63 | |||
Sequence: MEKVFSDEEISGNHHWSVNGMTSLNRSASEWAFNRFIQESSAAADDGESTTACGVSVSSPPNVPVDSEEYRAFLKSKLNLACAAVAMKRGTFIKPQDTSGRSDNGGANESEQASLASSKATPMMSSAITSGSELSGDEEEADGETNMNPTNVKRVKRMLSNRESARRSRRRKQAHLSELETQVSQLRVENSKLMKGLTDVTQTFNDASVENRVLKANIETLRAKVKMAEETVKRLTGFNPMFHNMPQIVSTVSLPSETSNSPDTTSSQVTTPEIISSGNKGKALIGCKMNRTASMRRVESLEHLQKRIRSVGDQ | ||||||
Modified residue | 29 | Phosphoserine; by KIN10 | ||||
Sequence: S | ||||||
Modified residue | 294 | Phosphoserine; by KIN10 | ||||
Sequence: S | ||||||
Modified residue | 300 | Phosphoserine; by KIN10 | ||||
Sequence: S |
Post-translational modification
Phosphorylated. The phosphorylation at Ser-29, Ser-294 and Ser-300 by KIN10 strongly enhances its ability to form homo- as well as heterodimers and are then essential for its transcriptional activity (PubMed:26263501).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in roots, shoots, young leaves, pollen, and flowers.
Induction
Strongly repressed by glucose.
Developmental stage
Present in silique valves, vasculature and funiculi.
Gene expression databases
Interaction
Subunit
Homodimer. Forms a heterodimer with LSD1, BZIP1, BZIP2, BZIP9, BZIP10, BZIP11, BZIP25, BZIP44 and BZIP53. Interacts with KIN10 and SNF4 (PubMed:26263501).
Component of a ternary complex composed of BZIP2-BZIP63 heterodimer and KIN10 (PubMed:29348240).
Component of a ternary complex composed of BZIP2-BZIP63 heterodimer and KIN10 (PubMed:29348240).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | B9DGI8 | BPM3 O22286 | 3 | EBI-942713, EBI-540923 | |
BINARY | B9DGI8 | BZIP1 Q9FGX2 | 4 | EBI-942713, EBI-942623 | |
BINARY | B9DGI8 | BZIP11 O65683 | 4 | EBI-942713, EBI-942769 | |
BINARY | B9DGI8 | BZIP2 Q9SI15 | 4 | EBI-942713, EBI-942735 | |
BINARY | B9DGI8 | BZIP44 C0Z2L5 | 4 | EBI-942713, EBI-942804 | |
BINARY | B9DGI8 | BZIP53 Q9LZP8 | 8 | EBI-942713, EBI-942845 | |
BINARY | B9DGI8 | BZIP63 B9DGI8 | 2 | EBI-942713, EBI-942713 | |
BINARY | B9DGI8 | GAI Q9LQT8 | 3 | EBI-942713, EBI-963606 | |
BINARY | B9DGI8 | RGL2 Q8GXW1 | 5 | EBI-942713, EBI-963665 | |
BINARY | B9DGI8 | RGL3 Q9LF53 | 3 | EBI-942713, EBI-15681313 | |
BINARY | B9DGI8-2 | At1g35490 C0SUZ3 | 3 | EBI-15191817, EBI-15192249 | |
BINARY | B9DGI8-2 | BZIP10 O22763-3 | 3 | EBI-15191817, EBI-15191815 | |
BINARY | B9DGI8-2 | BZIP44 C0Z2L5 | 3 | EBI-15191817, EBI-942804 | |
BINARY | B9DGI8-2 | BZIP6 O81002 | 3 | EBI-15191817, EBI-3133475 | |
BINARY | B9DGI8-2 | COL9 Q9SSE5 | 3 | EBI-15191817, EBI-15197469 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 94-177 | Disordered | ||||
Sequence: KPQDTSGRSDNGGANESEQASLASSKATPMMSSAITSGSELSGDEEEADGETNMNPTNVKRVKRMLSNRESARRSRRRKQAHLS | ||||||
Compositional bias | 95-133 | Polar residues | ||||
Sequence: PQDTSGRSDNGGANESEQASLASSKATPMMSSAITSGSE | ||||||
Domain | 151-214 | bZIP | ||||
Sequence: NVKRVKRMLSNRESARRSRRRKQAHLSELETQVSQLRVENSKLMKGLTDVTQTFNDASVENRVL | ||||||
Region | 153-172 | Basic motif | ||||
Sequence: KRVKRMLSNRESARRSRRRK | ||||||
Motif | 155-162 | Nuclear localization signal 1 | ||||
Sequence: VKRMLSNR | ||||||
Region | 179-193 | Leucine-zipper | ||||
Sequence: LETQVSQLRVENSKL | ||||||
Region | 253-274 | Disordered | ||||
Sequence: SLPSETSNSPDTTSSQVTTPEI | ||||||
Motif | 295-302 | Nuclear localization signal 2 | ||||
Sequence: MRRVESLE |
Sequence similarities
Belongs to the bZIP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
B9DGI8-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length314
- Mass (Da)34,311
- Last updated2009-03-24 v1
- Checksum37B85F20425DFF8B
B9DGI8-2
- Name2
- Differences from canonical
- 90-96: Missing
B9DGI8-3
- Name3
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8BBW4 | A0A1P8BBW4_ARATH | BZO2H3 | 225 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_042641 | 90-96 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 95-133 | Polar residues | ||||
Sequence: PQDTSGRSDNGGANESEQASLASSKATPMMSSAITSGSE | ||||||
Alternative sequence | VSP_042642 | 227-250 | in isoform 3 | |||
Sequence: MAEETVKRLTGFNPMFHNMPQIVS → YFLLSLCLPKLAIEACLFLAGENG | ||||||
Alternative sequence | VSP_042643 | 251-314 | in isoform 3 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF262041 EMBL· GenBank· DDBJ | AAF67360.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002688 EMBL· GenBank· DDBJ | AED93832.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED93833.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED93834.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF446876 EMBL· GenBank· DDBJ | AAL38609.1 EMBL· GenBank· DDBJ | mRNA | ||
AY052688 EMBL· GenBank· DDBJ | AAK96592.1 EMBL· GenBank· DDBJ | mRNA | ||
AK317169 EMBL· GenBank· DDBJ | BAH19855.1 EMBL· GenBank· DDBJ | mRNA | ||
AF310224 EMBL· GenBank· DDBJ | AAG25729.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ010858 EMBL· GenBank· DDBJ | CAC79656.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |