B9DGI8 · BZP63_ARATH

Function

function

Transcription factor involved in controlling responses to starvation (PubMed:26263501).
BZIP2-BZIP63-KIN10 complex binds to the ETFQO promoter to up-regulate its transcription (PubMed:29348240).

Activity regulation

Up-regulated by KIN10 under a phosphorylation-dependent manner.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionidentical protein binding
Molecular Functionkinase binding
Molecular Functionprotein heterodimerization activity
Biological Processcellular response to abscisic acid stimulus
Biological Processcellular response to glucose stimulus
Biological Processcellular response to starvation
Biological Processentrainment of circadian clock

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Basic leucine zipper 63
  • Short names
    AtbZIP63; bZIP protein 63
  • Alternative names
    • Basic leucine zipper OPAQUE 2 homolog 3 (Basic leucine zipper O2 homolog 3)

Gene names

    • Name
      BZIP63
    • Synonyms
      BZO2H3
    • ORF names
      T32B20.4
    • Ordered locus names
      At5g28770

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    B9DGI8
  • Secondary accessions
    • F4KA11
    • Q712P1
    • Q940U4
    • Q9FUD2
    • Q9LKT9

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus

Keywords

Phenotypes & Variants

Disruption phenotype

Starvation-related phenotype with reduced growth and accumulation of anthocyanins.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis29Reduces its activity. Abolishes the formation of the BZIP2-BZIP63 heterodimer; when associated with A-294 and A-300.
Mutagenesis160Normal DNA-binding.
Mutagenesis160Reduced DNA-binding to C-box motif.
Mutagenesis164Normal DNA-binding.
Mutagenesis164Impaired DNA-binding to C-box motif.
Mutagenesis168Normal DNA-binding.
Mutagenesis168Impaired DNA-binding to C-box motif.
Mutagenesis294Reduces activity. Abolishes the formation of the BZIP2-BZIP63 heterodimer; when associated with A-29 and A-300.
Mutagenesis300Reduces activity. Abolishes the formation of the BZIP2-BZIP63 heterodimer; when associated with A-29 and A-294.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 34 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004165601-314Basic leucine zipper 63
Modified residue29Phosphoserine; by KIN10
Modified residue294Phosphoserine; by KIN10
Modified residue300Phosphoserine; by KIN10

Post-translational modification

Phosphorylated. The phosphorylation at Ser-29, Ser-294 and Ser-300 by KIN10 strongly enhances its ability to form homo- as well as heterodimers and are then essential for its transcriptional activity (PubMed:26263501).

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in roots, shoots, young leaves, pollen, and flowers.

Induction

Strongly repressed by glucose.

Developmental stage

Present in silique valves, vasculature and funiculi.

Gene expression databases

Interaction

Subunit

Homodimer. Forms a heterodimer with LSD1, BZIP1, BZIP2, BZIP9, BZIP10, BZIP11, BZIP25, BZIP44 and BZIP53. Interacts with KIN10 and SNF4 (PubMed:26263501).
Component of a ternary complex composed of BZIP2-BZIP63 heterodimer and KIN10 (PubMed:29348240).

Binary interactions

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain, motif.

TypeIDPosition(s)Description
Region94-177Disordered
Compositional bias95-133Polar residues
Domain151-214bZIP
Region153-172Basic motif
Motif155-162Nuclear localization signal 1
Region179-193Leucine-zipper
Region253-274Disordered
Motif295-302Nuclear localization signal 2

Sequence similarities

Belongs to the bZIP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

B9DGI8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    314
  • Mass (Da)
    34,311
  • Last updated
    2009-03-24 v1
  • Checksum
    37B85F20425DFF8B
MEKVFSDEEISGNHHWSVNGMTSLNRSASEWAFNRFIQESSAAADDGESTTACGVSVSSPPNVPVDSEEYRAFLKSKLNLACAAVAMKRGTFIKPQDTSGRSDNGGANESEQASLASSKATPMMSSAITSGSELSGDEEEADGETNMNPTNVKRVKRMLSNRESARRSRRRKQAHLSELETQVSQLRVENSKLMKGLTDVTQTFNDASVENRVLKANIETLRAKVKMAEETVKRLTGFNPMFHNMPQIVSTVSLPSETSNSPDTTSSQVTTPEIISSGNKGKALIGCKMNRTASMRRVESLEHLQKRIRSVGDQ

B9DGI8-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

B9DGI8-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 227-250: MAEETVKRLTGFNPMFHNMPQIVS → YFLLSLCLPKLAIEACLFLAGENG
    • 251-314: Missing

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8BBW4A0A1P8BBW4_ARATHBZO2H3225

Sequence caution

The sequence AAF67360.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAC79656.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_04264190-96in isoform 2
Compositional bias95-133Polar residues
Alternative sequenceVSP_042642227-250in isoform 3
Alternative sequenceVSP_042643251-314in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF262041
EMBL· GenBank· DDBJ
AAF67360.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002688
EMBL· GenBank· DDBJ
AED93832.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED93833.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED93834.1
EMBL· GenBank· DDBJ
Genomic DNA
AF446876
EMBL· GenBank· DDBJ
AAL38609.1
EMBL· GenBank· DDBJ
mRNA
AY052688
EMBL· GenBank· DDBJ
AAK96592.1
EMBL· GenBank· DDBJ
mRNA
AK317169
EMBL· GenBank· DDBJ
BAH19855.1
EMBL· GenBank· DDBJ
mRNA
AF310224
EMBL· GenBank· DDBJ
AAG25729.1
EMBL· GenBank· DDBJ
mRNA
AJ010858
EMBL· GenBank· DDBJ
CAC79656.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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