Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative pro-apoptotic anti-autophagic and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway.
these results provide evidence that TRIM6 contributes to the antiviral response against WNV and identify VAMP8 as a novel regulator of the IFN-I system.
data show that defects in adaptor protein complex 3-dependent maturation of Weibel-Palade bodies impairs exocytosis by affecting the recruitment of VAMP8.
Cytotoxic granule exocytosis is a sequential multivesicle fusion process requiring VAMP8-mediated recycling endosome fusion before cytotoxic granule fusion.
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