B8ZTI5 · PCKG_MYCLB

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site81substrate
Binding site220-222substrate
Binding site229Mn2+ (UniProtKB | ChEBI)
Binding site249Mn2+ (UniProtKB | ChEBI)
Binding site271substrate
Binding site272-277GTP (UniProtKB | ChEBI)
Active site273
Binding site296Mn2+ (UniProtKB | ChEBI)
Binding site387-389substrate
Binding site389GTP (UniProtKB | ChEBI)
Binding site420GTP (UniProtKB | ChEBI)
Binding site515-518GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionGTP binding
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processgluconeogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK

Gene names

    • Name
      pckG
    • Ordered locus names
      MLBr02624

Organism names

Accessions

  • Primary accession
    B8ZTI5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001923451-609Phosphoenolpyruvate carboxykinase [GTP]

Interaction

Subunit

Monomer.

Structure

Family & Domains

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    609
  • Mass (Da)
    67,732
  • Last updated
    2009-03-03 v1
  • Checksum
    8916B6733622590B
MTSATIPGLDTAPTNHQKLLSWLEEVAELTHPAQVVFADGSDEEWQQLTERLVAAGTFKKLNDEKHPNSYLALSDPSDVARVESRTFICSEREIDAGPTNNWMDPAEMRSTMTELYRGCMRGRTMWVVPFCMGPPGAEDPKLGVEITDSEYVVASMKVMTRMGTSALEKIGDDGFFVKALHSVGAPLQPGQQDMPWPCNETKYITHFPETREIWSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKTNLAMLQPTIPGWRAETLGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMRTIAAGNTVFTNVALTDDNDVWWEGLEGEPAHLIDWKGNDWYAGKTETPAAHSNSRYCTPMSQCPILAPEWDDPRGVPISVILFGARRKTTVPLVTQARNWQHGVFMGATMGSEQTAAAEGKVGTVRRDPMAMLPFMGYHVGDYFQHWIDLGKHSDESNLPKVFFVNWFRRGEGGKFLWPGFGENSRVLKWIVDRIEHKAGGQDTLIGIVPTATDLDLDGLDISSDDVAKALAVDPAEWRNELPLIEEWFEFVGDKLPSGMQDEFEALKQRLAKED

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FM211192
EMBL· GenBank· DDBJ
CAR72724.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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