B8ZSC5 · END4_MYCLB

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

125220406080100120140160180200220240
TypeIDPosition(s)Description
Binding site56Zn2+ 1 (UniProtKB | ChEBI)
Binding site96Zn2+ 1 (UniProtKB | ChEBI)
Binding site129Zn2+ 1 (UniProtKB | ChEBI)
Binding site129Zn2+ 2 (UniProtKB | ChEBI)
Binding site162Zn2+ 2 (UniProtKB | ChEBI)
Binding site165Zn2+ 3 (UniProtKB | ChEBI)
Binding site191Zn2+ 2 (UniProtKB | ChEBI)
Binding site204Zn2+ 3 (UniProtKB | ChEBI)
Binding site206Zn2+ 3 (UniProtKB | ChEBI)
Binding site233Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • Ordered locus names
      MLBr01889

Organism names

Accessions

  • Primary accession
    B8ZSC5

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001233331-252Probable endonuclease 4

Structure

Family & Domains

Sequence similarities

Belongs to the AP endonuclease 2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    252
  • Mass (Da)
    26,861
  • Last updated
    2009-03-03 v1
  • Checksum
    B4A0A8C9E3F55EAC
MLIGSHVSSTDPLAAAEVEGADVVQIFLGNPQSWKAPTLRSDADVLKATALPVYVHAPYLINVASANSRVRIPSRKILQQTCDAAADIGAAAVVVHGGYVADDNDLEDGFQRWRKALDQLQTDVPVYLENTAGGDHAMARRFDTIARLWDVIGETGIGFCLDTCHAWAAGEGLIHVVDRIKAITGRIDLVHCNDSKDEAGSGRDRHANLGSGQIDAELLVAAVKVAGAPVICETAEEGRKDDIAFLREKTSG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FM211192
EMBL· GenBank· DDBJ
CAR71985.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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