B8ZSC5 · END4_MYCLB
- ProteinProbable endonuclease 4
- Genenfo
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids252 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
Catalytic activity
Cofactor
Note: Binds 3 Zn2+ ions.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 56 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 96 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 129 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 129 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 162 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 165 | Zn2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 191 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 204 | Zn2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 206 | Zn2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 233 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | deoxyribonuclease IV (phage-T4-induced) activity | |
Molecular Function | DNA binding | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | phosphoric diester hydrolase activity | |
Molecular Function | zinc ion binding | |
Biological Process | base-excision repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable endonuclease 4
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium
Accessions
- Primary accessionB8ZSC5
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000123333 | 1-252 | Probable endonuclease 4 | ||
Structure
Sequence
- Sequence statusComplete
- Length252
- Mass (Da)26,861
- Last updated2009-03-03 v1
- ChecksumB4A0A8C9E3F55EAC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FM211192 EMBL· GenBank· DDBJ | CAR71985.1 EMBL· GenBank· DDBJ | Genomic DNA |