B8ZS08 · PPK1_MYCLB
- ProteinPolyphosphate kinase
- Geneppk
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids739 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
Catalytic activity
- [phosphate](n) + ATP = [phosphate](n+1) + ADP
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 87 | ATP (UniProtKB | ChEBI) | |||
Binding site | 428 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 458 | Mg2+ (UniProtKB | ChEBI) | |||
Active site | 488 | Phosphohistidine intermediate | |||
Binding site | 521 | ATP (UniProtKB | ChEBI) | |||
Binding site | 621 | ATP (UniProtKB | ChEBI) | |||
Binding site | 649 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | polyphosphate kinase complex | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | polyphosphate kinase activity | |
Biological Process | phosphorylation | |
Biological Process | polyphosphate biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePolyphosphate kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium
Accessions
- Primary accessionB8ZS08
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000133405 | 1-739 | Polyphosphate kinase | ||
Post-translational modification
An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 22-45 | Disordered | |||
Compositional bias | 30-45 | Polar residues | |||
Region | 714-739 | Disordered | |||
Sequence similarities
Belongs to the polyphosphate kinase 1 (PPK1) family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length739
- Mass (Da)83,288
- Last updated2009-03-03 v1
- Checksum21B5C61834DFBED5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 30-45 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FM211192 EMBL· GenBank· DDBJ | CAR71776.1 EMBL· GenBank· DDBJ | Genomic DNA |