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B8ZQK0 · LIPB_MYCLB

Function

function

Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.

Miscellaneous

In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

Pathway

Protein modification; protein lipoylation via endogenous pathway; protein N6-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site78-85substrate
Site147Lowers pKa of active site Cys
Binding site150-152substrate
Binding site163-165substrate
Active site181Acyl-thioester intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionlipoyl(octanoyl) transferase activity
Biological Processprotein lipoylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Octanoyltransferase
  • EC number
  • Alternative names
    • Lipoate-protein ligase B
    • Lipoyl/octanoyl transferase
    • Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase

Gene names

    • Name
      lipB
    • Ordered locus names
      MLBr00859

Organism names

Accessions

  • Primary accession
    B8ZQK0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001165501-235Octanoyltransferase

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain37-220BPL/LPL catalytic

Sequence similarities

Belongs to the LipB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    235
  • Mass (Da)
    25,002
  • Last updated
    2009-03-03 v1
  • MD5 Checksum
    EFB3138B4694ED35CD43B1B8BB4FF400
MDSIRSIPTAIDVRQLGTVDYHIAWQLQRDLADARVAGGPDTLLLLQHPPVYTAGRRTQPHERPNPSLHGVPVVETDRGGKITWHGPGQLVGYPIIGLAEPLDVVNYVRRLEEALIKVCAELGLDTSRVNGRSGIWVPGSAGQPARKIAAIGVRVSRATTMHGFALNCQCDLDAFHAIVPCGISDAGVTSLSAELGRTVAVNDVRSAIAEAVNDALDGWLALSWLSTPASVTSTL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FM211192
EMBL· GenBank· DDBJ
CAR70954.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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