B8ZN14 · THIM1_STRPJ

Function

function

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site39substrate
Binding site115ATP (UniProtKB | ChEBI)
Binding site160ATP (UniProtKB | ChEBI)
Binding site187substrate

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionhydroxyethylthiazole kinase activity
Molecular Functionmagnesium ion binding
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hydroxyethylthiazole kinase 1
  • EC number
  • Alternative names
    • 4-methyl-5-beta-hydroxyethylthiazole kinase 1
      (TH kinase 1
      ; Thz kinase 1
      )

Gene names

    • Name
      thiM1
    • Ordered locus names
      SPN23F06420

Organism names

Accessions

  • Primary accession
    B8ZN14

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001981311-260Hydroxyethylthiazole kinase 1

Structure

Family & Domains

Sequence similarities

Belongs to the Thz kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    260
  • Mass (Da)
    27,635
  • Last updated
    2009-03-03 v1
  • Checksum
    B1846DA024C97404
MTSLKLLKEKAPLVICITNDVVKNFTANGLVALGASPAMSEFPADLEDLLKYAGGLLINIGTLTDENWKLYQAALKIAEKYNVPVVLDPVACGAGEYRKKVADDLINNYKLAAIRGNAGEIASLVGIDVASKGVDSAGVDNIDEIALAANEKFNIPIVVTGEVDAIAVNGEVVTIHNGSAMMPKVIGTGCLLGAVVASFIGLEKGQELKSLETAMLVYNIAGEMAEKRPNGHLPGTFKVEFINALYEITDEDVKEFKRVK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FM211187
EMBL· GenBank· DDBJ
CAR68489.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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