our data indicate that S-nitrosylation of parkin leading to p53-mediated neuronal cell death contributes to the pathophysiology of sporadic Parkinson's disease
a parkin-dependent ER-stress-associated modulation of DJ-1 and identifies p53 and XBP-1 as two major actors acting downstream of parkin in this signaling cascade in cells and in vivo.
interbreeding of Park2 heterozygous knockout mice with Apc(Min) mice resulted in a dramatic acceleration of intestinal adenoma development and increased polyp multiplicity
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